Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …

Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Standard induction chemotherapy, consisting of an anthracycline and cytarabine, has been
the first-line therapy for many years to treat acute myeloid leukemia (AML). Although this …

Haematopoiesis is governed by haematopoietic stem cells (HSCs) that produce all lineages
of blood and immune cells. The maintenance of blood homeostasis requires a dynamic …

Non-genetic drug resistance is increasingly recognised in various cancers. Molecular
insights into this process are lacking and it is unknown whether stable non-genetic …

Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid
leukemia (AML) with MLL translocations. The assumption has been that differentiation is …

A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the
translational implications for putative epigenetic therapies targeted against them …

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders
characterized by activated Janus kinase (JAK)–signal transducer and activator of …

Acute myeloid leukemia is characterized by arrested differentiation, and agents that
overcome this block are therapeutically useful, as shown by the efficacy of all-trans retinoic …

Hematopoiesis is the process by which both fetal and adult organisms derive the full
repertoire of blood cells from a single multipotent progenitor cell type, the hematopoietic …