The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Dopamine is a brain neurotransmitter involved in the pathology of schizophrenia. The
dopamine hypothesis states that, in schizophrenia, dopaminergic signal transduction is …

The transport of N‐methyl‐d‐aspartate receptors (NMDAR s) is crucial for neuronal plasticity
and synapse formation. Here, we show that KIF 3B, a member of the kinesin superfamily …

Background The synaptic hypothesis is an influential theory of the pathoetiology of
schizophrenia (SCZ), which is supported by the finding that there is lower uptake of the …

Neuroinflammation induced by peripheral infections leads to various neuropsychiatric
symptoms both in humans and laboratory animals, eg, to the manifestation of sickness …

Psychiatric genetic studies have identified genome-wide significant loci for schizophrenia.
The AKT3/1q44 locus is a principal risk region and gene-network analyses identify AKT3 …

The genes encoding for neuregulin1 (NRG1), a growth factor, and its receptor ErbB4 are
both risk factors of major depression disorder and schizophrenia (SZ). They have been …

Alternative splicing of schizophrenia risk genes, such as DRD2, GRM3, and DISC1, has
been extensively described. Nevertheless, the alternative splicing characteristics of the …

The serine/threonine protein kinase v-AKT homologs (AKTs), are implicated in typical and
atypical neurodevelopment. Akt isoforms Akt1, Akt2, and Akt3 have been extensively studied …

Cortical disinhibition is a common feature of several neuropsychiatric diseases such as
schizophrenia, autism and intellectual disabilities. However, the underlying mechanisms are …