Acute myeloid leukaemia
CD DiNardo, HP Erba, SD Freeman, AH Wei - The Lancet, 2023 - thelancet.com
Progress in acute myeloid leukaemia treatment is occurring at an unprecedented pace. The
past decade has witnessed an increasingly improved scientific understanding of the …
past decade has witnessed an increasingly improved scientific understanding of the …
Clonal haematopoiesis and dysregulation of the immune system
Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …
Prediction of risk for myeloid malignancy in clonal hematopoiesis
Background Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of
undetermined significance (CCUS) are defined by somatic mutations in genes associated …
undetermined significance (CCUS) are defined by somatic mutations in genes associated …
Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia
EJ Duncavage, A Bagg, RP Hasserjian… - Blood, The Journal …, 2022 - ashpublications.org
Myeloid neoplasms and acute leukemias derive from the clonal expansion of hematopoietic
cells driven by somatic gene mutations. Although assessment of morphology plays a crucial …
cells driven by somatic gene mutations. Although assessment of morphology plays a crucial …
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN
The 2010 and 2017 editions of the European LeukemiaNet (ELN) recommendations for
diagnosis and management of acute myeloid leukemia (AML) in adults are widely …
diagnosis and management of acute myeloid leukemia (AML) in adults are widely …
Germ line predisposition variants occur in myelodysplastic syndrome patients of all ages
S Feurstein, AM Trottier, N Estrada-Merly… - Blood, The Journal …, 2022 - ashpublications.org
The frequency of pathogenic/likely pathogenic (P/LP) germ line variants in patients with
myelodysplastic syndrome (MDS) diagnosed at age 40 years or less is 15% to 20 …
myelodysplastic syndrome (MDS) diagnosed at age 40 years or less is 15% to 20 …
Clonal hematopoiesis, somatic mosaicism, and age-associated disease
MA Evans, K Walsh - Physiological Reviews, 2023 - journals.physiology.org
Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis
Clonal hematopoiesis resulting from the enhanced fitness of mutant hematopoietic stem
cells (HSC) associates with both favorable and unfavorable health outcomes related to the …
cells (HSC) associates with both favorable and unfavorable health outcomes related to the …
Cellular barcoding to decipher clonal dynamics in disease
Cellular barcodes are distinct DNA sequences that enable one to track specific cells across
time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes …
time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes …
Haematopoietic stem-cell transplantation in China in the era of targeted therapies: current advances, challenges, and future directions
YJ Chang, XY Pei, XJ Huang - The Lancet Haematology, 2022 - thelancet.com
In the era of targeted therapies, haematopoietic stem-cell transplantation (HSCT), both
allogeneic and autologous, remains a curative approach for patients with chemosensitive …
allogeneic and autologous, remains a curative approach for patients with chemosensitive …