Size, source and chemical composition as determinants of toxicity attributable to ambient particulate matter

FJ Kelly, JC Fussell - Atmospheric environment, 2012 - Elsevier
Particulate matter (PM) is a complex, heterogeneous mixture that changes in time and
space. It encompasses many different chemical components and physical characteristics …

Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association

RD Brook, S Rajagopalan, CA Pope III, JR Brook… - Circulation, 2010 - Am Heart Assoc
In 2004, the first American Heart Association scientific statement on “Air Pollution and
Cardiovascular Disease” concluded that exposure to particulate matter (PM) air pollution …

Particulate matter–induced health effects: who is susceptible?

JD Sacks, LW Stanek, TJ Luben… - Environmental …, 2011 - ehp.niehs.nih.gov
Background Epidemiological, controlled human exposure, and toxicological studies have
demonstrated a variety of health effects in response to particulate matter (PM) exposure with …

Toxicological and epidemiological studies of cardiovascular effects of ambient air fine particulate matter (PM2.5) and its chemical components: Coherence and public …

M Lippmann - Critical reviews in toxicology, 2014 - Taylor & Francis
Recent investigations on PM2. 5 constituents' effects in community residents have
substantially enhanced our knowledge on the impacts of specific components, especially the …

Key characteristics of cardiovascular toxicants

L Lind, JA Araujo, A Barchowsky… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: The concept of chemical agents having properties that confer potential hazard
called key characteristics (KCs) was first developed to identify carcinogenic hazards …

[HTML][HTML] Role of autonomic reflex arcs in cardiovascular responses to air pollution exposure

CM Perez, MS Hazari, AK Farraj - Cardiovascular toxicology, 2015 - Springer
The body responds to environmental stressors by triggering autonomic reflexes in the
pulmonary receptors, baroreceptors, and chemoreceptors to maintain homeostasis …

[HTML][HTML] Cardiovascular health and particulate vehicular emissions: a critical evaluation of the evidence

TJ Grahame, RB Schlesinger - Air Quality, Atmosphere & Health, 2010 - Springer
A major public health goal is to determine linkages between specific pollution sources and
adverse health outcomes. This paper provides an integrative evaluation of the database …

Health effects of concentrated ambient air particulate matter (CAPs) and its components

M Lippmann, LC Chen - Critical reviews in toxicology, 2009 - Taylor & Francis
We review literature that provides insights on health-related effects observed in laboratory-
based inhalation studies in humans and laboratory animals using concentrated ambient air …

TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust

MS Hazari, N Haykal-Coates, DW Winsett… - Environmental …, 2011 - ehp.niehs.nih.gov
Background: Diesel exhaust (DE), which is emitted from on-and off-road sources, is a
complex mixture of toxic gaseous and particulate components that leads to triggered …

Acute cardiovascular and inflammatory toxicity induced by inhalation of diesel and biodiesel exhaust particles

JM Brito, L Belotti, AC Toledo… - Toxicological …, 2010 - academic.oup.com
Abstract Analysis of fuel emissions is crucial for understanding the pathogenesis of mortality
because of air pollution. The objective of this study is to assess cardiovascular and …