Cancer is the world's major health issue, scavenging lives of millions throughout the world. A
number of anticancer drugs have figured prominently in the diagnosis and treatment of …

A novel series of purine benzimidazole hybrids were designed and synthesized for the first
time with the aim to circumvent the increasing antibiotic resistance. Hexyl appended hybrid …

A new “turn-on” fluorescent probe (PTAHN) based on a biological purine derivative for
detecting Zn2+ was designed, synthesized and characterized. The PTAHN exhibited …

An efficient route without metal catalyst has been developed for synthesis of 4-
biphenylamino-5-halo-2 (5H)-furanones. The antitumor activities against various tumor cells …

The Purine moiety is regarded as the ubiquitous nitrogen-containing heterocycle in nature
and is recognized as a privileged scaffold in medicinal chemistry. Moreover, the purine …

A series of small molecules, theophylline acetohydrazide hydrazone derivatives were
obtained via condensation of theophylline‐7‐acetohydrazide with different …

We designed, prepared and evaluated a new ligand Ethyl 2-(4-(5, 9-dihydro-6-hydroxy-2-
mercapto-4H-purin-8-ylthio) thiophen-2-yl)-2-oxoacetate for anticancer activity against a …

A series of novel alkyl substituted purines were synthesized. 6‐[4‐(4‐Propoxyphenyl)
piperazin‐1‐yl]‐9H‐purine was used as the key starting material, which was synthesized via …

Abstract P70-S6K1 & PI3K-δ kinases are identified to be involved in many physiological
processes associated with cancer, therefore many of the inhibitors being designed to target …

ABSTRACT A novel series of 6-chloro-7-methyl-5 H-[1, 3, 4] thiadiazolo [3, 2-a] pyrimidin-5-
one derivatives were synthesized. Structure of the newly synthesized compounds was …