Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide
natural products is strongly influenced by how they are released from their biosynthetic …

Covering: up to September 2009 This review covers the recent literature on the release
mechanisms for polyketides and nonribosomal peptides produced by microorganisms. The …

Time span of literature covered: up to mid-2023 Iterative type I polyketide synthases (iPKSs)
are outstanding natural chemists: megaenzymes that repeatedly utilize their catalytic …

Thioesterases are enzymes that hydrolyze thioester bonds in numerous biochemical
pathways, for example in fatty acid synthesis. This work reports known functions, structures …

Thioesterases (TEs) are classified into EC 3.1. 2.1 through EC 3.1. 2.27 based on their
activities on different substrates, with many remaining unclassified (EC 3.1. 2.–). Analysis of …

Alka (e) nes are ideal fuel components for aviation, long-distance transport, and shipping.
They are typically derived from fossil fuels and accounting for 24% of difficult-to-eliminate …

A large number of antibiotics and other industrially important microbial secondary
metabolites are synthesized by polyketide synthases (PKSs) and nonribosomal peptide …

The enediynes are structurally characterized by a 1, 5-diyne-3-ene motif within a 9-or 10-
membered enediyne core. The anthraquinone-fused enediynes (AFEs) are a subclass of 10 …

Covering: up to the end of July, 2021 Anthraquinone-fused enediynes (AFEs) are a
subfamily of enediyne natural products. Dynemicin A (DYN A), the first member of the AFE …

Alkyne-containing natural products are important molecules that are widely distributed in
microbes and plants. Inspired by the advantages of acetylenic products used in the fields of …