Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer
disease (AD) and Parkinson disease (PD). One in ten individuals aged≥ 65 years has AD …

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss
of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …

Background The global population of older individuals is growing, and ageing is a key risk
factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells …

From the dawn of civilization, humanity has dreamed of immortality. So why didn't the
discovery of the anti-aging properties of mTOR inhibitors change the world forever? I will …

COVID-19 is not deadly early in life, but mortality increases exponentially with age, which is
the strongest predictor of mortality. Mortality is higher in men than in women, because men …