Clinical utility of liquid biopsy-based actionable mutations detected via ddPCR

I Palacín-Aliana, N García-Romero, A Asensi-Puig… - Biomedicines, 2021 - mdpi.com
Cancer is one of the leading causes of death worldwide and remains a major public health
challenge. The introduction of more sensitive and powerful technologies has permitted the …

Beyond blood: Advancing the frontiers of liquid biopsy in oncology and personalized medicine

Y Bao, D Zhang, H Guo, W Ma - Cancer Science, 2024 - Wiley Online Library
Liquid biopsy is emerging as a pivotal tool in precision oncology, offering a noninvasive and
comprehensive approach to cancer diagnostics and management. By harnessing biofluids …

Accelerating the development and validation of liquid biopsy for early cancer screening and treatment tailoring

D Horgan, T Čufer, F Gatto, I Lugowska, D Verbanac… - Healthcare, 2022 - mdpi.com
Liquid biopsy (LB) is a minimally invasive method which aims to detect circulating tumor-
derived components in body fluids. It provides an alternative to current cancer screening …

Current and new frontiers in hereditary cancer surveillance: Opportunities for liquid biopsy

KM Farncombe, D Wong, ML Norman… - The American Journal of …, 2023 - cell.com
At least 5% of cancer diagnoses are attributed to a causal pathogenic or likely pathogenic
germline genetic variant (hereditary cancer syndrome—HCS). These individuals are …

Best practices in qPCR and dPCR validation in regulated bioanalytical laboratories

A Hays, R Islam, K Matys, D Williams - The AAPS journal, 2022 - Springer
The use of molecular techniques in the bioanalytical laboratory is becoming more common
as the number of gene and cell therapy products continues to increase. Currently, there is no …

Long non‐coding RNA as a potential diagnostic and prognostic biomarker in melanoma: a systematic review and meta‐analysis

M Masrour, S Khanmohammadi… - Journal of Cellular …, 2024 - Wiley Online Library
Recently, long noncoding RNAs (lncRNAs) have been applied as biomarkers for melanoma
patients. In this systematic review and meta‐analysis, we investigated the diagnostic and …

[HTML][HTML] Role of ctDNA for the detection of minimal residual disease in resected non-small cell lung cancer: a systematic review

M Verzè, M Pluchino, A Leonetti… - Translational Lung …, 2022 - ncbi.nlm.nih.gov
Background Operable stage I-III non-small cell lung cancer (NSCLC) has a high risk of
recurrence, mainly due to remnant clones of the disease defined as minimal residual …

Clinical utility of liquid biopsy in breast cancer: A systematic review

G Duque, C Manterola, T Otzen, C Arias… - Clinical …, 2022 - Wiley Online Library
Advancements in genetic sequencing techniques along with the identification of specific
mutations and structural changes in multiple cancer genes, make it possible to identify …

Circulating H3K27 methylated nucleosome plasma concentration: synergistic information with circulating tumor DNA molecular profiling

E Grolleau, J Candiracci, G Lescuyer, D Barthelemy… - Biomolecules, 2023 - mdpi.com
The molecular profiling of circulating tumor DNA (ctDNA) is a helpful tool not only in cancer
treatment, but also in the early detection of relapse. However, the clinical interpretation of a …

liquid biopsy holds a promising approach for the early detection of cancer; current information and future perspectives

AM Shbeer, IA Robadi - Pathology-Research and Practice, 2024 - Elsevier
Cancer is becoming a global pandemic, and its occurrence is increasing rapidly, putting a
strain on people's families, health systems, and finances, in addition to their physical …