Improving clinical trial outcomes in amyotrophic lateral sclerosis

MC Kiernan, S Vucic, K Talbot, CJ McDermott… - Nature Reviews …, 2021 - nature.com
Individuals who are diagnosed with amyotrophic lateral sclerosis (ALS) today face the same
historically intransigent problem that has existed since the initial description of the disease in …

[HTML][HTML] Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee

S Vucic, KHS Chen, MC Kiernan, M Hallett… - Clinical …, 2023 - Elsevier
The review provides a comprehensive update (previous report: Chen R, Cros D, Curra A, Di
Lazzaro V, Lefaucheur JP, Magistris MR, et al. The clinical diagnostic utility of transcranial …

Pharmacotherapy for amyotrophic lateral sclerosis: a review of approved and upcoming agents

SA Johnson, T Fang, F De Marchi, D Neel… - Drugs, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
involving loss of upper and lower motor neurons, with most cases ending in death within 3–5 …

Effect of ezogabine on cortical and spinal motor neuron excitability in amyotrophic lateral sclerosis: a randomized clinical trial

BJ Wainger, EA Macklin, S Vucic, CE McIlduff… - JAMA …, 2021 - jamanetwork.com
Importance Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
of the motor nervous system. Clinical studies have demonstrated cortical and spinal motor …

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

V Deora, JD Lee, EA Albornoz, L McAlary, CJ Jagaraj… - Glia, 2020 - Wiley Online Library
Microglial NLRP3 inflammasome activation is emerging as a key contributor to
neuroinflammation during neurodegeneration. Pathogenic protein aggregates such as β …

Pathophysiology and diagnosis of ALS: insights from advances in neurophysiological techniques

MAJ van den Bos, N Geevasinga… - International journal of …, 2019 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative
disorder of the motor neurons, characterized by focal onset of muscle weakness and …

Motor potentials evoked by transcranial magnetic stimulation: interpreting a simple measure of a complex system

DA Spampinato, J Ibanez, L Rocchi… - The Journal of …, 2023 - Wiley Online Library
Transcranial magnetic stimulation (TMS) is a non‐invasive technique that is increasingly
used to study the human brain. One of the principal outcome measures is the motor‐evoked …

Risk factors and emerging therapies in amyotrophic lateral sclerosis

N Nowicka, J Juranek, JK Juranek… - International journal of …, 2019 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease
characterized by a permanent degeneration of both upper and lower motor neurons. Many …

Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS

K Weskamp, EM Tank, R Miguez… - The Journal of …, 2020 - Am Soc Clin Investig
Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are highly
conserved features in amyotrophic lateral sclerosis (ALS). Nevertheless, the relationship …

Riluzole, disease stage and survival in ALS

T Dharmadasa, MC Kiernan - The Lancet Neurology, 2018 - thelancet.com
Comment 386 www. thelancet. com/neurology Vol 17 May 2018 might be an early transient
effect, with other molecular pathways becoming more involved later. Such a proposition …