The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

ROS production by mitochondria: function or dysfunction?

FR Palma, BN Gantner, MJ Sakiyama, C Kayzuka… - Oncogene, 2024 - nature.com
In eukaryotic cells, ATP generation is generally viewed as the primary function of
mitochondria under normoxic conditions. Reactive oxygen species (ROS), in contrast, are …

ROS signalling in the biology of cancer

JN Moloney, TG Cotter - Seminars in cell & developmental biology, 2018 - Elsevier
Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …

Biomimetic Design of Mitochondria‐Targeted Hybrid Nanozymes as Superoxide Scavengers

Y Zhang, A Khalique, X Du, Z Gao, J Wu… - Advanced …, 2021 - Wiley Online Library
Abstract Development of enzyme mimics for the scavenging of excessive mitochondrial
superoxide (O2•−) can serve as an effective strategy in the treatment of many diseases …

Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

X Mu, W Shi, Y Xu, C Xu, T Zhao, B Geng, J Yang… - Cell cycle, 2018 - Taylor & Francis
Tumor-associated macrophages (TAM) are prominent components of tumor
microenvironment (TME) and capable of promoting cancer progression. However, the …

AMP-activated protein kinase: An energy sensor and survival mechanism in the reinstatement of metabolic homeostasis

A Sharma, SK Anand, N Singh, UN Dwivedi… - Experimental cell …, 2023 - Elsevier
Cells are programmed to favorably respond towards the nutrient availability by adapting
their metabolism to meet energy demands. AMP-activated protein kinase (AMPK) is a highly …

Insights into manganese superoxide dismutase and human diseases

M Liu, X Sun, B Chen, R Dai, Z Xi, H Xu - International Journal of …, 2022 - mdpi.com
Redox equilibria and the modulation of redox signalling play crucial roles in physiological
processes. Overproduction of reactive oxygen species (ROS) disrupts the body's antioxidant …

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

EC Hinchy, AV Gruszczyk, R Willows… - Journal of Biological …, 2018 - ASBMB
Mitochondrial reactive oxygen species (ROS) production is a tightly regulated redox signal
that transmits information from the organelle to the cell. Other mitochondrial signals, such as …

Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression

S Sui, S Xu, D Pang - Pharmacology & therapeutics, 2022 - Elsevier
Breast cancer has become a serious threat to women's health. Cancer progression is mainly
derived from resistance to apoptosis induced by procedures or therapies. Therefore, new …

[HTML][HTML] An insight on superoxide dismutase (SOD) from plants for mammalian health enhancement

S Stephenie, YP Chang, A Gnanasekaran… - Journal of Functional …, 2020 - Elsevier
Superoxide dismutase (SOD) is an antioxidant enzyme functional for physiological defense
strategies in animals and plants against free radicals and reactive oxygen species (ROS) …