Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Cyclin-dependent kinase 9 (CDK9), a member of the cyclin-dependent protein kinase (CDK)
family, is involved in transcriptional elongation of several target genes. CDK9 is ubiquitously …

Cyclins and cyclin-dependent protein kinases (CDKs) are important regulatory components
that are required for cell cycle progression. The levels of the cell cycle CDKs are generally …

Simple Summary CDK9, in combination with Cyclin T1, is one of the major regulators of RNA
Polymerase II mediated productive transcription of critical genes in any cell. The activity of …

Abstract Development of selective kinase inhibitors that target the ATP binding site
continues to be a challenge largely due to similar binding pockets. Palbociclib is a cyclin …

Wogonin is a natural product isolated from the Scutellaria baicalensis and has been proved
to be a potent and selective inhibitor of CDK9. Using this scaffold, we designed and …

Current treatment for acute myeloid leukemia (AML) is less than optimal, but increased
understanding of disease pathobiology and genomics has led to clinical investigation of …

The positive transcription elongation factor b (P-TEFb) stimulates transcriptional elongation
by phosphorylating the carboxy-terminal domain of RNA polymerase II and antagonizing the …

Abstract Cyclin‐Dependent Kinase 9 (CDK9) is part of a functional diverse group of
enzymes responsible for cell cycle control and progression. It associates mainly with Cyclin …