The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …

The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related
serine/threonine kinases that regulate diverse cellular processes, including cell growth …

Entry into mitosis is triggered by the activation of cyclin‐dependent kinase 1 (Cdk1). This
simple reaction rapidly and irreversibly sets the cell up for division. Even though the core …

Constitutive nuclear factor κB (NF-κB) activation is a hallmark of colon tumor growth. Cyclin-
dependent kinases (CDKs) are critical cell-cycle regulators, and inhibition of CDK activity …

Background MicroRNAs are short (∼ 22 nt) non-coding regulatory RNAs that control gene
expression at the post-transcriptional level. Here the functional impact of microRNAs on cell …

Cells are equipped with a cell-intrinsic signaling network called the DNA damage response
(DDR). This signaling network recognizes DNA lesions and initiates various downstream …

Mammalian oocytes spend the majority of their lives in a dormant state, residing in
primordial follicles. This arrest, most analogous to the G2 stage of the mitotic cell cycle …

Infectious bursal disease virus (IBDV) is a double-stranded RNA (dsRNA) virus belonging to
the genus Avibirnavirus in the family Birnaviridae. It can cause serious failure of vaccination …

Cyclin-dependent kinases (CDKs) play key roles in cell cycle regulation. Genetic analysis in
mice has revealed an essential role for Cdk2 in meiosis, which renders Cdk2 knockout (KO) …

The aim of the present study was to evaluate the antitumor mechanism of dihydromyricetin
(DHM). Results showed that DHM significantly inhibited cell viability of HepG2 and Hep3B …