The distinct roles of zinc finger CCHC-type (ZCCHC) superfamily proteins in the regulation of RNA metabolism

Y Wang, Y Yu, Y Pang, H Yu, W Zhang, X Zhao… - RNA biology, 2021 - Taylor & Francis
The zinc finger CCHC-type (ZCCHC) superfamily proteins, characterized with the consensus
sequence C-X2-C-X4-H-X4-C, are accepted to have high-affinity binding to single-stranded …

Role of Arabidopsis Splicing factor SF1 in Temperature-Responsive Alternative Splicing of FLM pre-mRNA

KC Lee, KS Chung, HT Lee, JH Park, JH Lee… - Frontiers in Plant …, 2020 - frontiersin.org
Small changes in temperature affect plant ecological and physiological factors that impact
agricultural production. Hence, understanding how temperature affects flowering is crucial …

COX5B-mediated bioenergetic alteration regulates tumor growth and migration by modulating AMPK-UHMK1-ERK cascade in hepatoma

YD Chu, WR Lin, YH Lin, WH Kuo, CJ Tseng, SN Lim… - Cancers, 2020 - mdpi.com
The oxidative phosphorylation machinery in mitochondria, which generates the main
bioenergy pool in cells, includes four enzyme complexes for electron transport and ATP …

The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface

S Loerch, JR Leach, SW Horner, D Maji… - Journal of Biological …, 2019 - ASBMB
The transcription elongation and pre-mRNA splicing factor Tat-SF1 associates with the U2
small nuclear ribonucleoprotein (snRNP) of the spliceosome. However, the direct binding …

Cancer-associated mutations mapped on high-resolution structures of the U2AF2 RNA recognition motifs

E Glasser, AA Agrawal, JL Jenkins, CL Kielkopf - Biochemistry, 2017 - ACS Publications
Acquired point mutations of pre-mRNA splicing factors recur among cancers, leukemias, and
related neoplasms. Several studies have established that somatic mutations of a U2AF1 …

UHMK1 promotes lung adenocarcinoma oncogenesis by regulating the PI3K/AKT/mTOR signaling pathway

Y Li, S Wang, K Jin, W Jin, L Si, H Zhang… - Thoracic Cancer, 2023 - Wiley Online Library
Background Effective targeted therapy for lung adenocarcinoma (LUAD), the number one
cancer killer worldwide, continues to be a difficult problem because of the limitation of …

A UHM–ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

JW Galardi, VN Bela, N Jeffery, X He, E Glasser… - Journal of Biological …, 2022 - ASBMB
During spliceosome assembly, the 3′ splice site is recognized by sequential U2AF2
complexes, first with Splicing Factor 1 (SF1) and second by the SF3B1 subunit of the U2 …

[HTML][HTML] Bioinformatics analysis of gene expression profiles for risk prediction in patients with septic shock

Y Hu, L Cheng, W Zhong, M Chen… - Medical science monitor …, 2019 - ncbi.nlm.nih.gov
Bioinformatics Analysis of Gene Expression Profiles for Risk Prediction in Patients with Septic
Shock - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …

UHMK1 is a novel splicing regulatory kinase

VC Arfelli, YC Chang, JW Bagnoli, P Kerbs… - Journal of Biological …, 2023 - ASBMB
The U2AF Homology Motif Kinase 1 (UHMK1) is the only kinase that contains the U2AF
homology motif, a common protein interaction domain among splicing factors. Through this …

Intrinsic Disorder and Salt-dependent Conformational Changes of the N-terminal TFIP11 Splicing Factor

B Juniku, J Mignon, A Genco, AM Obeid, D Mottet… - ACS Omega, 2024 - orbi.uliege.be
AbstractTuftelin Interacting Protein 11 (TFIP11) was recently identified as a critical human
spliceosome assembly regulator. Indeed, it is involved in many biological functions including …