Catalytic metal-enabled story of isocyanides for use as “C1N1” synthons in cyclization: beyond radical chemistry

D Chen, J Li, X Wang, Y Shan, K Huang… - Organic Chemistry …, 2022 - pubs.rsc.org
Cyclization reactions have attracted considerable attention in organic synthesis with regard
to high atom economy and synthetic efficiency towards cyclic architectures. In particular …

Silver‐Catalyzed Asymmetric Dearomatization of Electron‐Deficient Heteroarenes via Interrupted Barton–Zard Reaction

Q Wan, JH Xie, C Zheng, YF Yuan… - Angewandte Chemie, 2021 - Wiley Online Library
Herein we report a catalytic asymmetric dearomatization reaction of electron‐deficient
heteroarenes with α‐substituted isocyanoacetates through an interrupted Barton–Zard …

Multicomponent Reactions Based on In Situ Generated Isocyanides for the Construction of Heterocycles

SI Bhat, M Kigga, MM Heravi - Chemistry of Heterocyclic Compounds, 2021 - Springer
Isocyanides have a long history, high versatility and have been used widely in various
research fields, especially in multicomponent synthesis. Despite their many applications …

Metal‐Free Electrochemical [3+2] Cycloaddition between α‐Amino Carbonyls and Tosylmethyl Isocyanide en route to Substituted Imidazoles

S Mallick, M Baidya, S De Sarkar - Advanced Synthesis & …, 2024 - Wiley Online Library
The established strategy unveils a metal and mediator‐free electrochemical [3+ 2]
cycloaddition approach among α‐amino carbonyls and tosylmethyl isocyanide (TosMIC) …

BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor

D Meibom, P Wasnaire, K Beyer, A Broehl… - Journal of Medicinal …, 2024 - ACS Publications
The matrix metalloprotease ADAMTS7 has been identified by multiple genome-wide
association studies as being involved in the development of coronary artery disease …

Base-Promoted [4 + 2] Annulation Reaction of In Situ-Generated Azadienes from N-Propargylamines with Active Methylene Compounds: Access to Highly …

BK Behera, PJ Arandhara, B Porashar… - The Journal of …, 2023 - ACS Publications
A facile and efficient synthesis of structurally diversified 2-pyridones is demonstrated using
the [4+ 2] annulation of in situ generated azadienes from N-propargylamines and active …

1,2,3-Benzotriazine Synthesis by Heterocyclization of p-Tosylmethyl Isocyanide Derivatives

F Maqueda-Zelaya, JL Aceña, E Merino… - The Journal of …, 2023 - ACS Publications
An efficient methodology to form 4-alkoxy-and 4-aryloxybenzo [d][1, 2, 3] triazines via an
intramolecular heterocyclization of 1-azido-2-[isocyano (p-tosyl) methyl] benzenes under …

Copper Loading-Controlled Selective Synthesis of 2, 5-Bis (trifluoromethyl) and Monotrifluoromethyl-Substituted Oxazoles

W Wu, Z Zhang, J Li, J Xia, X Han… - The Journal of Organic …, 2023 - ACS Publications
A general domino annulation reaction of sulfonylmethyl isocyanide with trifluoroacetic
anhydride in the presence of copper chloride as an additive is developed. The reaction …

Cp* Ir (iii) complexes catalyzed solvent-free synthesis of quinolines, pyrroles and pyridines via an ADC strategy

M Bakibillah, S Reja, K Sarkar, D Mukherjee… - Organic & …, 2024 - pubs.rsc.org
A trio of Ir (III) complexes that are held together by a picolinamidato moiety were created. In
our earlier research, we demonstrated the catalytic activity of the complexes for producing …

Visible‐Light Induced Oxidative Annulation of Enamides to 2, 4, 5‐Trisubstituted Oxazole Skeletons

DN Wang, Q Lin, X Wang, K Zhang… - Asian Journal of …, 2023 - Wiley Online Library
A novel approach to various trisubstituted oxazoles (28 examples, up to 88% yield) has
been developed via 9H‐thioxanthen‐9‐one (TX) mediated oxidative annulation of N‐acetyl …