Catalytic metal-enabled story of isocyanides for use as “C1N1” synthons in cyclization: beyond radical chemistry
D Chen, J Li, X Wang, Y Shan, K Huang… - Organic Chemistry …, 2022 - pubs.rsc.org
Cyclization reactions have attracted considerable attention in organic synthesis with regard
to high atom economy and synthetic efficiency towards cyclic architectures. In particular …
to high atom economy and synthetic efficiency towards cyclic architectures. In particular …
Silver‐Catalyzed Asymmetric Dearomatization of Electron‐Deficient Heteroarenes via Interrupted Barton–Zard Reaction
Q Wan, JH Xie, C Zheng, YF Yuan… - Angewandte Chemie, 2021 - Wiley Online Library
Herein we report a catalytic asymmetric dearomatization reaction of electron‐deficient
heteroarenes with α‐substituted isocyanoacetates through an interrupted Barton–Zard …
heteroarenes with α‐substituted isocyanoacetates through an interrupted Barton–Zard …
Multicomponent Reactions Based on In Situ Generated Isocyanides for the Construction of Heterocycles
Isocyanides have a long history, high versatility and have been used widely in various
research fields, especially in multicomponent synthesis. Despite their many applications …
research fields, especially in multicomponent synthesis. Despite their many applications …
Metal‐Free Electrochemical [3+2] Cycloaddition between α‐Amino Carbonyls and Tosylmethyl Isocyanide en route to Substituted Imidazoles
The established strategy unveils a metal and mediator‐free electrochemical [3+ 2]
cycloaddition approach among α‐amino carbonyls and tosylmethyl isocyanide (TosMIC) …
cycloaddition approach among α‐amino carbonyls and tosylmethyl isocyanide (TosMIC) …
BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor
D Meibom, P Wasnaire, K Beyer, A Broehl… - Journal of Medicinal …, 2024 - ACS Publications
The matrix metalloprotease ADAMTS7 has been identified by multiple genome-wide
association studies as being involved in the development of coronary artery disease …
association studies as being involved in the development of coronary artery disease …
Base-Promoted [4 + 2] Annulation Reaction of In Situ-Generated Azadienes from N-Propargylamines with Active Methylene Compounds: Access to Highly …
A facile and efficient synthesis of structurally diversified 2-pyridones is demonstrated using
the [4+ 2] annulation of in situ generated azadienes from N-propargylamines and active …
the [4+ 2] annulation of in situ generated azadienes from N-propargylamines and active …
1,2,3-Benzotriazine Synthesis by Heterocyclization of p-Tosylmethyl Isocyanide Derivatives
F Maqueda-Zelaya, JL Aceña, E Merino… - The Journal of …, 2023 - ACS Publications
An efficient methodology to form 4-alkoxy-and 4-aryloxybenzo [d][1, 2, 3] triazines via an
intramolecular heterocyclization of 1-azido-2-[isocyano (p-tosyl) methyl] benzenes under …
intramolecular heterocyclization of 1-azido-2-[isocyano (p-tosyl) methyl] benzenes under …
Copper Loading-Controlled Selective Synthesis of 2, 5-Bis (trifluoromethyl) and Monotrifluoromethyl-Substituted Oxazoles
W Wu, Z Zhang, J Li, J Xia, X Han… - The Journal of Organic …, 2023 - ACS Publications
A general domino annulation reaction of sulfonylmethyl isocyanide with trifluoroacetic
anhydride in the presence of copper chloride as an additive is developed. The reaction …
anhydride in the presence of copper chloride as an additive is developed. The reaction …
Cp* Ir (iii) complexes catalyzed solvent-free synthesis of quinolines, pyrroles and pyridines via an ADC strategy
A trio of Ir (III) complexes that are held together by a picolinamidato moiety were created. In
our earlier research, we demonstrated the catalytic activity of the complexes for producing …
our earlier research, we demonstrated the catalytic activity of the complexes for producing …
Visible‐Light Induced Oxidative Annulation of Enamides to 2, 4, 5‐Trisubstituted Oxazole Skeletons
DN Wang, Q Lin, X Wang, K Zhang… - Asian Journal of …, 2023 - Wiley Online Library
A novel approach to various trisubstituted oxazoles (28 examples, up to 88% yield) has
been developed via 9H‐thioxanthen‐9‐one (TX) mediated oxidative annulation of N‐acetyl …
been developed via 9H‐thioxanthen‐9‐one (TX) mediated oxidative annulation of N‐acetyl …