The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

In the mitochondrial outer membrane, α-helical transmembrane proteins play critical roles in
cytoplasmic-mitochondrial communication. Using genome-wide CRISPR screens, we …

Bax and Bak are members of the Bcl‐2 family and core regulators of the intrinsic pathway of
apoptosis. Upon apoptotic stimuli, they are activated and oligomerize at the mitochondrial …

Members of the mitochondrial carrier family (SLC25) provide the transport steps for amino
acids, carboxylic acids, fatty acids, cofactors, inorganic ions, and nucleotides across the …

Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis
that activates the caspase cascade and irreversibly causes the majority of cells to die. The …

Apoptosis is a critically important biological process that plays an essential role in cell fate
and homeostasis. An important component of the apoptotic pathway is the family of proteins …

The Bcl-2 family of proteins controls a critical step in commitment to apoptosis by regulating
permeabilization of the mitochondrial outer membrane (MOM). The family is divided into …

Mitochondria participate in apoptosis through a range of mechanisms that vary between
vertebrates and invertebrates. In vertebrates, they release intermembrane space proteins …