BMP signalling in skeletal development, disease and repair

VS Salazar, LW Gamer, V Rosen - Nature Reviews Endocrinology, 2016 - nature.com
Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer
of bone and cartilage formation, BMP superfamily signalling has become one of the most …

Bone morphogenetic proteins

T Katagiri, T Watabe - Cold Spring Harbor Perspectives …, 2016 - cshperspectives.cshlp.org
Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …

[HTML][HTML] Biologics for tendon repair

D Docheva, SA Müller, M Majewski… - Advanced drug delivery …, 2015 - Elsevier
Tendon injuries are common and present a clinical challenge to orthopedic surgery mainly
because these injuries often respond poorly to treatment and require prolonged …

Tendon and ligament regeneration and repair: clinical relevance and developmental paradigm

G Yang, BB Rothrauff, RS Tuan - Birth defects research part C …, 2013 - Wiley Online Library
As dense connective tissues connecting bone to muscle and bone to bone, respectively,
tendon and ligament (T/L) arise from the somitic mesoderm, originating in a recently …

TGF-β family signaling in mesenchymal differentiation

I Grafe, S Alexander, JR Peterson… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

Bone morphogenetic proteins: a critical review

B Bragdon, O Moseychuk, S Saldanha, D King… - Cellular signalling, 2011 - Elsevier
Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the
Transforming Growth Factor Beta superfamily. To date over 20 members have been …

Tendon injuries: Basic science and new repair proposals

F Wu, M Nerlich, D Docheva - EFORT open reviews, 2017 - eor.bioscientifica.com
Tendons connect muscles to bones, ensuring joint movement. With advanced age, tendons
become more prone to degeneration followed by injuries. Tendon repair often requires …

Tendon injury and tendinopathy: healing and repair

P Sharma, N Maffulli - JBJS, 2005 - journals.lww.com
Tendon Injury and Tendinopathy: Healing and Repair : JBJS Tendon Injury and Tendinopathy:
Healing and Repair : JBJS JBJS Journal Case Connector Reviews JBJS.org Surgical …

Pathogenesis of tendinopathies: inflammation or degeneration?

M Abate, K Gravare Silbernagel, C Siljeholm… - Arthritis research & …, 2009 - Springer
The intrinsic pathogenetic mechanisms of tendinopathies are largely unknown and whether
inflammation or degeneration has the prominent role is still a matter of debate. Assuming …

Mesenchymal stromal cells: biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation

CM Kolf, E Cho, RS Tuan - Arthritis research & therapy, 2007 - Springer
Recent advances in understanding the cellular and molecular signaling pathways and
global transcriptional regulators of adult mesenchymal stem cells have provided new …