Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Clear cell renal cell carcinoma (ccRCC) is the most frequent histological kidney cancer
subtype. Over the last decade, significant progress has been made in identifying the genetic …

Introduction Lipidomics focuses on the in-depth analysis of lipids, which are crucial
macromolecules involved in a wide range of metabolic pathways. The increased …

Metastasis of tumor cells from primary sites of malignancy to neighboring stromal tissue or
distant localities entails in several instances, but not in every case, the epithelial …

Chemoresistance remains a major complication of cancer treatments. Recent data provide
strong evidence that chemoresistance is linked to epithelial–mesenchymal transition (EMT) …

Epithelial–mesenchymal plasticity (EMP) plays critical roles during embryonic development,
wound repair, fibrosis, inflammation and cancer. During cancer progression, EMP results in …

Cancer cells adapt to varying stress conditions to survive through plasticity. Stem cells
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …

Ubiquitin–proteasome system (UPS) is a selective proteolytic system that is associated with
the expression or function of target proteins and participates in various physiological and …

Abstract SNAI2/SLUG, a metastasis-promoting transcription factor, is a labile protein that is
degraded through the ubiquitin proteasome degradation system. Here, we conducted …

Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …