Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation.
Inflammation is one common and effective physiological event that protects against various …

The solute carrier family 7 member 11 (SLC7A11), an amino acid transporter protein is
frequently overexpressed in human malignancies. The expression and activity of SLC7A11 …

Retinal pigment epithelium (RPE) degeneration plays an important role in a group of retinal
disorders such as retinal degeneration (RD) and age-related macular degeneration (AMD) …

Intervertebral disc degeneration (IVDD) is a common pathological condition responsible for
lower back pain, which can significantly increase economic and social burdens. Although …

Abstract Lysine-specific demethylase 1 (LSD1) has been identified as an important
epigenetic target, and recent advances in lung cancer therapy have highlighted the …

Cellular senescence is a hallmark of aging and has been linked to age-related diseases.
Age-related macular degeneration (AMD), the most common aging-related retinal disease …

The elevated level of interferon-γ (IFN-γ) in Sjogren's syndrome (SS) triggers salivary gland
epithelial cells (SGEC) death. However, the underlying mechanisms of IFN-γ-induced SGEC …

Ferroptosis is a newly discovered form of regulated cell death. Ferroptosis is an iron-
dependent lipid peroxidation reaction of cell membrane lipids, and it is closely related to the …

Background: Ferroptosis induced by SLC7A11 has an important translational value in the
treatment of cancers. However, the mechanism of SLC7A11 in the pathogenesis of colon …

Ferroptosis is a kind of iron-dependent renewal programmed death. Its main mechanism is
to catalyze the unsaturated fatty acids highly expressed on the cell membrane under the …