Oleanolic acid: extraction, characterization and biological activity

JM Castellano, S Ramos-Romero, JS Perona - Nutrients, 2022 - mdpi.com
Oleanolic acid, a pentacyclic triterpenoid ubiquitously present in the plant kingdom, is
receiving outstanding attention from the scientific community due to its biological activity …

The effects of type 2 diabetes mellitus on organ metabolism and the immune system

G Daryabor, MR Atashzar, D Kabelitz, S Meri… - Frontiers in …, 2020 - frontiersin.org
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …

The crucial role and mechanism of insulin resistance in metabolic disease

X Zhao, X An, C Yang, W Sun, H Ji… - Frontiers in endocrinology, 2023 - frontiersin.org
Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …

[HTML][HTML] Mechanisms of insulin action and insulin resistance

MC Petersen, GI Shulman - Physiological reviews, 2018 - journals.physiology.org
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

[HTML][HTML] The PI3K/AKT pathway in obesity and type 2 diabetes

X Huang, G Liu, J Guo, Z Su - International journal of biological …, 2018 - ncbi.nlm.nih.gov
Obesity and type 2 diabetes mellitus are complicated metabolic diseases that affect multiple
organs and are characterized by hyperglycaemia. Currently, stable and effective treatments …

The key role of mitochondrial function in health and disease

I San-Millán - Antioxidants, 2023 - mdpi.com
The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

M Flockhart, LC Nilsson, S Tais, B Ekblom, W Apró… - Cell metabolism, 2021 - cell.com
Exercise training positively affects metabolic health through increased mitochondrial
oxidative capacity and improved glucose regulation and is the first line of treatment in …

[HTML][HTML] Wearable hydrogel patch with noninvasive, electrochemical glucose sensor for natural sweat detection

PH Lin, SC Sheu, CW Chen, SC Huang, BR Li - Talanta, 2022 - Elsevier
Recent advances in microelectronics and electrochemical sensing platforms have preceded
the development of devices for personal monitoring and managing physiological and …

The essential element manganese, oxidative stress, and metabolic diseases: links and interactions

L Li, X Yang - Oxidative medicine and cellular longevity, 2018 - Wiley Online Library
Manganese (Mn) is an essential element that is involved in the synthesis and activation of
many enzymes and in the regulation of the metabolism of glucose and lipids in humans. In …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in metabolic disorders—A step towards mitochondria based therapeutic strategies

JS Bhatti, GK Bhatti, PH Reddy - … et Biophysica Acta (BBA)-Molecular Basis …, 2017 - Elsevier
Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …