Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Stimulus-responsive sequential release systems for drug and gene delivery

S Ahmadi, N Rabiee, M Bagherzadeh, F Elmi, Y Fatahi… - Nano today, 2020 - Elsevier
In recent years, a range of studies have been conducted with the aim to design and
characterize delivery systems that are able to release multiple therapeutic agents in …

The immune reaction and degradation fate of scaffold in cartilage/bone tissue engineering

D Yang, J Xiao, B Wang, L Li, X Kong, J Liao - Materials Science and …, 2019 - Elsevier
Tissue engineering with scaffolds provides novel prospects for bone/cartilage damage
healing. Previous studies mainly focus on the development of physical/chemical property of …

Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries

W Ong, C Pinese, SY Chew - Advanced drug delivery reviews, 2019 - Elsevier
Neural tissue regeneration following traumatic injuries is often subpar. As a result, the field
of neural tissue engineering has evolved to find therapeutic interventions and has seen …

Recent Developments in Layer‐by‐Layer Assembly for Drug Delivery and Tissue Engineering Applications

J Borges, J Zeng, XQ Liu, H Chang… - Advanced …, 2024 - Wiley Online Library
Surfaces with biological functionalities are of great interest for biomaterials, tissue
engineering, biophysics, and for controlling biological processes. The layer‐by‐layer (LbL) …

Dual-responsive nanoparticles based on oxidized pullulan and a disulfide-containing poly (β-amino) ester for efficient delivery of genes and chemotherapeutic agents …

H Wang, G Wan, Y Liu, B Chen, H Chen, S Zhang… - Polymer …, 2016 - pubs.rsc.org
A dual-responsive nanoparticle system was designed based on oxidized pullulan (oxPL)
and a disulfide-containing poly (β-amino) ester (ssPBAE) for the efficient delivery of genes …

Reduction sensitive PEG hydrogels for codelivery of antigen and adjuvant to induce potent CTLs

CH Kapadia, S Tian, JL Perry, JC Luft… - Molecular …, 2016 - ACS Publications
Educating our immune system via vaccination is an attractive approach to combat infectious
diseases. Eliciting antigen specific cytotoxic T cells (CTLs), CD8+ effector T cells, is essential …

[HTML][HTML] Dual drug delivery collagen vehicles for modulation of skin fibrosis in vitro

JQ Coentro, A Di Nubila, U May, S Prince… - Biomedical …, 2022 - iopscience.iop.org
Single molecule drug delivery systems have failed to yield functional therapeutic outcomes,
triggering investigations into multi-molecular drug delivery vehicles. In the context of skin …

Nanomechanical behavior of high gas barrier multilayer thin films

M Humood, S Chowdhury, Y Song… - … applied materials & …, 2016 - ACS Publications
Nanoindentation and nanoscratch experiments were performed on thin multilayer films
manufactured using the layer-by-layer (LbL) assembly technique. These films are known to …

Visible-light-responsive polymeric multilayers for trapping and release of cargoes via host–guest interactions

Q Bian, M Jin, S Chen, L Xu, S Wang, G Wang - Polymer Chemistry, 2017 - pubs.rsc.org
A novel visible light responsive polymeric multilayer was constructed by layer-by-layer (LbL)
electrostatic self-assembly, from which the trapping/release of cargoes via azobenzene …