Down syndrome (DS) is the most commonly identified genetic form of mental retardation and
the leading cause of specific birth defects and medical conditions. Traditional …

Almost 15 years ago it was hypothesized that polymorphisms of genes encoding enzymes
involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …

Polymorphisms in folate pathway genes may influence the susceptibility to acute
lymphoblastic leukemia (ALL). DNA was isolated from 245 pediatric ALL patients (cases) …

Alzheimer's disease (AD) represents the most common form of dementia in the elderly,
characterized by progressive loss of memory and cognitive capacity severe enough to …

Background Several studies around the world support the hypothesis that genetic
polymorphisms involved in folate metabolism could be related to the maternal risk for Down …

Background Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate
metabolic pathway which catalyzes the irreversible conversion of 5, 10 …

Folates are essential nutrients that are required for one-carbon biosynthetic and epigenetic
processes. A deficiency in cellular folates results in aberrant DNA methylation, point …

BACKGROUND: Orofacial clefts (OFCs) are one of the most common birth defects in
humans. Maternal use of folate antagonists including dihydrofolate reductase inhibitors has …

We analyzed the role of six common polymorphisms in folate metabolizing genes as
possible risk factors for having a child with Down syndrome (DS) in 94 Italian mothers of a …