The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity

N Lehnert, E Kim, HT Dong, JB Harland… - Chemical …, 2021 - ACS Publications
Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Desulfonylation via radical process: recent developments in organic synthesis

XQ Chu, D Ge, YY Cui, ZL Shen, CJ Li - Chemical reviews, 2021 - ACS Publications
As the “chemical chameleon”, sulfonyl-containing compounds and their variants have been
merged with various types of reactions for the efficient construction of diverse molecular …

[HTML][HTML] Cobalt-catalyzed atroposelective C− H activation/annulation to access N− N axially chiral frameworks

T Li, L Shi, X Wang, C Yang, D Yang, MP Song… - Nature …, 2023 - nature.com
The N− N atropisomer, as an important and intriguing chiral system, was widely present in
natural products, pharmaceutical lead compounds, and advanced material skeletons. The …

Organocatalytic atroposelective synthesis of N− N axially chiral indoles and pyrroles by de novo ring formation

KW Chen, ZH Chen, S Yang, SF Wu… - Angewandte Chemie …, 2022 - Wiley Online Library
The first highly atroposelective construction of N− N axially chiral indole scaffolds was
established via a new strategy of de novo ring formation. This strategy makes use of the …

Enantioselective synthesis of nitrogen–nitrogen biaryl atropisomers via copper-catalyzed Friedel–Crafts alkylation reaction

XM Wang, P Zhang, Q Xu, CQ Guo… - Journal of the …, 2021 - ACS Publications
Nitrogen–nitrogen bonds containing motifs are ubiquitous in natural products and bioactive
compounds. However, the atropisomerism arising from a restricted rotation around an N–N …

Enantioselective synthesis of N− N bisindole atropisomers

P Zhang, Q Xu, XM Wang, J Feng, CJ Lu… - Angewandte …, 2022 - Wiley Online Library
N− N Atropisomers are a common motif in natural products and represent a significant
dimension for exploration in modern pharmaceutical and medicinal chemistry. However, the …

Photochemical and electrochemical strategies in C–F bond activation and functionalization

Z Wang, Y Sun, LY Shen, WC Yang… - Organic Chemistry …, 2022 - pubs.rsc.org
The activation and functionalization of C–F bonds under mild conditions can serve as an
important tool for organic syntheses including the modification of pharmaceuticals and …

[HTML][HTML] Rational design and atroposelective synthesis of N–N axially chiral compounds

GJ Mei, JJ Wong, W Zheng, AA Nangia, KN Houk, Y Lu - Chem, 2021 - cell.com
The first catalytic asymmetric synthesis of N–N axially chiral compounds has been
accomplished via a quinidine catalyzed N-allylic alkylation reaction. These N–N axially …

Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation

R Verma, SK Verma, KP Rakesh, YR Girish… - European journal of …, 2021 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA) is becoming lethal to humanity due to
easy transmission and difficult-to-treat skin and flimsy diseases. The most threatening aspect …

[HTML][HTML] Organocatalytic diastereo-and atroposelective construction of N–N axially chiral pyrroles and indoles

SJ Wang, X Wang, X Xin, S Zhang, H Yang… - Nature …, 2024 - nature.com
The construction of N–N axially chiral motifs is an important research topic, owing to their
wide occurrence in natural products, pharmaceuticals and chiral ligands. One efficient …