Decoding the interplay between genetic and non-genetic drivers of metastasis
Metastasis is a multistep process by which cancer cells break away from their original
location and spread to distant organs, and is responsible for the vast majority of cancer …
location and spread to distant organs, and is responsible for the vast majority of cancer …
Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma
IK Kim, MS Diamond, S Yuan, SB Kemp… - Nature …, 2024 - nature.com
Acquired resistance to immunotherapy remains a critical yet incompletely understood
biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma …
biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma …
[HTML][HTML] Adaptive therapy: a tumor therapy strategy based on Darwinian evolution theory
L Zhang, J Ma, L Liu, G Li, H Li, Y Hao, X Zhang… - Critical Reviews in …, 2023 - Elsevier
Cancer progression is a dynamic process of continuous evolution, in which genetic diversity
and heterogeneity are generated by clonal and subclonal amplification based on random …
and heterogeneity are generated by clonal and subclonal amplification based on random …
Clonal differences underlie variable responses to sequential and prolonged treatment
Cancer cells exhibit dramatic differences in gene expression at the single-cell level, which
can predict whether they become resistant to treatment. Treatment perpetuates this …
can predict whether they become resistant to treatment. Treatment perpetuates this …
[HTML][HTML] Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy
Acquired resistance to immune checkpoint immunotherapy remains a critical yet
incompletely understood biological mechanism. Here, using a mouse model of pancreatic …
incompletely understood biological mechanism. Here, using a mouse model of pancreatic …
Leveraging Cancer Phenotypic Plasticity for Novel Treatment Strategies
Cancer cells, like all other organisms, are adept at switching their phenotype to adjust to the
changes in their environment. Thus, phenotypic plasticity is a quantitative trait that confers a …
changes in their environment. Thus, phenotypic plasticity is a quantitative trait that confers a …
[HTML][HTML] Single‐cell isogrowth profiling: Uniform inhibition uncovers non‐uniform drug responses
M Lukačišin, A Espinosa‐Cantú… - Clinical and …, 2022 - ncbi.nlm.nih.gov
Non-genetic inter-cellular heterogeneity, in which cells from a population sharing the same
genome exhibit phenotypic variability, is increasingly recognised as a major variable …
genome exhibit phenotypic variability, is increasingly recognised as a major variable …