Specific enzymes play key roles in many pathophysiological processes and therefore are
targets for therapeutic strategies. The activity of most enzymes is largely determined by …

Single-molecule fluorescence spectroscopy is emerging as an important tool for studying
biomolecular folding dynamics. Its usefulness stems from its ability to directly map …

Optimized coupling protocols are presented for the efficient and automated generation of
carboxyfluorescein-labeled peptides. Side products, generated when applying earlier …

In this study, we explored the fractionation and identification of antibacterial peptides from
cottonseed protein hydrolysates obtained using Alcalase. The cottonseed protein …

We demonstrated previously the involvement of a nicotinic acetylcholinereceptor containing
an α7 subunit in the human sperm acrosome reaction (a modified exocytotic event essential …

Two new probes for the detection of calpain I activity based on fluorescence resonance
energy transfer technology have been synthesized and evaluated. The probes incorporated …

Highly site-selective dimethyl labeling of N-terminus of peptides has been obtained by
adjusting the acidic strength of the reaction solution. And this selective labeling strategy …

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To detect the local polarity such as the N-terminal domain of a protein molecule, 3-(4-chloro-
6-hydrazino-1, 3, 5-triazinylamino)-7-(dimethylamino)-2-methylphenazine has been …

An economical and preparative-scale orthogonal solid-phase method of incorporating
carboxyrhodamine and carboxyfluorescein fluorescence resonance energy transfer (FRET) …