IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation

W Ouyang, A O'Garra - Immunity, 2019 - cell.com
Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …

IL-10 and IL-22 in mucosal immunity: driving protection and pathology

HX Wei, B Wang, B Li - Frontiers in Immunology, 2020 - frontiersin.org
The barrier surfaces of the gastrointestinal tract are in constant contact with various
microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the …

Interleukin-22: immunobiology and pathology

JA Dudakov, AM Hanash… - Annual review of …, 2015 - annualreviews.org
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …

Therapeutic opportunities of the IL-22–IL-22R1 system

R Sabat, W Ouyang, K Wolk - Nature reviews Drug discovery, 2014 - nature.com
Abstract Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells,
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …

Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases

M Akdis, S Burgler, R Crameri, T Eiwegger… - Journal of allergy and …, 2011 - Elsevier
Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

GF Sonnenberg, LA Fouser, D Artis - Nature immunology, 2011 - nature.com
The maintenance of barrier function at exposed surfaces of the mammalian body is essential
for limiting exposure to environmental stimuli, preventing systemic dissemination of …

Interleukin-10 and the interleukin-10 receptor

KW Moore, R de Waal Malefyt… - Annual review of …, 2001 - annualreviews.org
Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

C James, V Ugo, JP Le Couédic, J Staerk… - nature, 2005 - nature.com
Myeloproliferative disorders are clonal haematopoietic stem cell malignancies characterized
by independency or hypersensitivity of haematopoietic progenitors to numerous cytokines …

IL‐22, not simply a Th17 cytokine

S Rutz, C Eidenschenk, W Ouyang - Immunological reviews, 2013 - Wiley Online Library
Summary Interleukin‐22 (IL‐22) has important functions in host defense at mucosal surfaces
as well as in tissue repair. It is unique as a cytokine that is produced by immune cells …

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

S Trifari, CD Kaplan, EH Tran, NK Crellin, H Spits - Nature immunology, 2009 - nature.com
Abstract Interleukin 22 (IL-22) is a member of the IL-10 cytokine family that is involved in
inflammatory and wound healing processes. Originally considered a T helper type 1 (TH1) …