Interactions between lncRNAs and cyclins/CDKs complexes; key players in determining cancer cell response to CDKs inhibitors
BI Saeed, A Kumar, EF Oghenemaro… - Experimental Cell …, 2025 - Elsevier
Transcription takes place over a significant portion of the human genome. However, only a
small portion of the transcriptome, roughly 1.2%, consists of RNAs translated into proteins; …
small portion of the transcriptome, roughly 1.2%, consists of RNAs translated into proteins; …
An image-based screen for secreted proteins involved in breast cancer G0 cell cycle arrest
WA Weston, JA Holt, AJ Wiecek, J Pilling… - Scientific Data, 2024 - nature.com
Secreted proteins regulate the balance between cellular proliferation and G0 arrest and
therefore play important roles in tumour dormancy. Tumour dormancy presents a significant …
therefore play important roles in tumour dormancy. Tumour dormancy presents a significant …
Binding Modalities and Phase-Specific Regulation of Cyclin/Cyclin-Dependent Kinase Complexes in the Cell Cycle
Cyclin-dependent kinases (CDKs) are activated upon cyclin-binding to enable progression
through the cell cycle. Dominant CDKs and cyclins in mammalian cells include CDK1 …
through the cell cycle. Dominant CDKs and cyclins in mammalian cells include CDK1 …
Sanguinarine identified as a natural dual inhibitor of AURKA and CDK2 through network pharmacology and bioinformatics approaches
X Li, Q You - Scientific Reports, 2024 - nature.com
Cervical cancer (CA) continues to be a female malignant tumor with limited therapeutic
options, resulting in a high mortality rate. Sanguinarine (SANG), a naturally occurring …
options, resulting in a high mortality rate. Sanguinarine (SANG), a naturally occurring …
A reverse brake for the cell cycle
B Westendorp - Science, 2024 - science.org
Cancer cells often have abnormal DNA content owing to disruption of the pathways that
control the cell cycle. Cells commit to the cell cycle in response to small peptide signals …
control the cell cycle. Cells commit to the cell cycle in response to small peptide signals …
Molecular Mechanisms Maintaining Cell Cycle Arrest Induced by Pharmacological CDK4/6 Inhibition
BL Mouery - 2024 - search.proquest.com
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) promote cell cycle entry by
phosphorylating and inactivating the retinoblastoma (RB) protein, allowing for expression of …
phosphorylating and inactivating the retinoblastoma (RB) protein, allowing for expression of …
[HTML][HTML] The ribotoxic stress response drives UV-mediated cell death
While ultraviolet (UV) radiation damages DNA, eliciting the DNA damage response (DDR), it
also damages RNA, triggering transcriptome-wide ribosomal collisions and eliciting a …
also damages RNA, triggering transcriptome-wide ribosomal collisions and eliciting a …