Advances in immunotherapy have revolutionized cancer treatment, yet many patients do not
show clinical responses. While most immunotherapies target T cells, myeloid cells are the …

Immunotherapy, including immune checkpoint inhibition, has transformed cancer therapy in
recent years, providing new and potentially curative options for patients with even advanced …

Fcγ receptors (FcγRs) play key roles in the effector function of IgG, but their inappropriate
activation plays a role in several disease etiologies. Therefore, it is critical to better …

Simple Summary In cancer patients, immunotherapy using targeted antibodies is often not
effective in the long term due to resistance mechanisms developed by cancer cells. Tumors …

Since the successful introduction of checkpoint inhibitors targeting the adaptive immune
system, monoclonal antibodies inhibiting CD47-SIRPα interaction have shown promise in …

Glycosylation of proteins and lipids in mammals is essential for embryogenesis and the
development of all tissues. Analyses of glycosylation mutants in cultured mammalian cells …

Simple Summary In this review, we will focus on the interactions between tumor-associated
MUC1 (cell-surface mucin) and Siglecs (sialic-acid-binding lectins). These interactions play …

Despite the curative potential of checkpoint blockade immunotherapy, a majority of patients
remain unresponsive to existing treatments. Glyco-immune checkpoints–interactions of cell …

Glycosylation is the most structurally diverse form of post-translational modification (PTM) of
proteins that affects a myriad of cellular processes. As a pivotal regulator of protein …

Myeloid cells accumulate extensively in most tumors and play a critical role in
immunosuppression of the tumor microenvironment (TME). Like T cells, myeloid cells also …