[HTML][HTML] The advent of plant cells in bioreactors

F Verdú-Navarro, JA Moreno-Cid, J Weiss… - Frontiers in Plant …, 2023 - frontiersin.org
Ever since agriculture started, plants have been bred to obtain better yields, better fruits, or
sustainable products under uncertain biotic and abiotic conditions. However, a new way to …

Modulating antibody effector functions by Fc glycoengineering

M García-Alija, B Van Moer, DE Sastre, T Azzam… - Biotechnology …, 2023 - Elsevier
Antibody based drugs, including IgG monoclonal antibodies, are an expanding class of
therapeutics widely employed to treat cancer, autoimmune and infectious diseases. IgG …

Mannans and mannan oligosaccharides (MOS) from Saccharomyces cerevisiae–A sustainable source of functional ingredients

M Faustino, J Durão, CF Pereira, ME Pintado… - Carbohydrate …, 2021 - Elsevier
Sustainable industry practices and circular economy concepts encourage the transformation
of production waste into by-products. Saccharomyces cerevisiae is widely used in …

[HTML][HTML] Structural and In Vitro Functional Analyses of Novel Plant-Produced Anti-Human PD1 Antibody

K Rattanapisit, T Phakham, S Buranapraditkun… - Scientific reports, 2019 - nature.com
Immunotherapy has emerged as a promising and effective treatment for cancer. The
frequently used immunotherapy agents are immune checkpoint inhibitors, such as …

[HTML][HTML] From farm to finger prick—a perspective on how plants can help in the fight against COVID-19

KA McDonald, RB Holtz - Frontiers in Bioengineering and …, 2020 - frontiersin.org
As a consequence of the COVID-19 pandemic crisis, farmers across the country are plowing
under their fields and laying off workers. Plant biomass has been shown by the DARPA …

[HTML][HTML] Glycoengineering of therapeutic antibodies with small molecule inhibitors

S Li, AJ McCraw, RA Gardner, DIR Spencer… - Antibodies, 2021 - mdpi.com
Monoclonal antibodies (mAbs) are one of the cornerstones of modern medicine, across an
increasing range of therapeutic areas. All therapeutic mAbs are glycoproteins, ie, their …

[HTML][HTML] Impact of Specific N-Glycan Modifications on the Use of Plant-Produced SARS-CoV-2 Antigens in Serological Assays

J Schwestka, J König-Beihammer, YJ Shin… - Frontiers in Plant …, 2021 - frontiersin.org
The receptor binding domain (RBD) of the SARS-CoV-2 spike protein plays a key role in the
virus-host cell interaction, and viral infection. The RBD is a major target for neutralizing …

[HTML][HTML] Effects of N-glycosylation on the structure, function, and stability of a plant-made Fc-fusion anthrax decoy protein

Y Xiong, K Karuppanan, A Bernardi, Q Li… - Frontiers in Plant …, 2019 - frontiersin.org
Protein N-glycosylation is an important post-translational modification and has influences on
a variety of biological processes at the cellular and molecular level, making glycosylation a …

[HTML][HTML] Host cell glycocalyx remodeling reveals SARS-CoV-2 spike protein glycomic binding sites

Y Sheng, A Vinjamuri, MRS Alvarez, Y Xie… - Frontiers in Molecular …, 2022 - frontiersin.org
Glycans on the host cell membrane and viral proteins play critical roles in pathogenesis.
Highly glycosylated epithelial cells represent the primary boundary separating embedded …

[HTML][HTML] Production of Biopharmaceuticals in Nicotiana benthamiana—Axillary Stem Growth as a Key Determinant of Total Protein Yield

MC Goulet, L Gaudreau, M Gagné… - Frontiers in Plant …, 2019 - frontiersin.org
Data are scarce about the influence of basic cultural conditions on growth patterns and
overall performance of plants used as heterologous production hosts for protein …