Stalled protein synthesis produces defective nascent chains that can harm cells. In
response, cells degrade these nascent chains via a process called ribosome-associated …

Autosomal dominant oculopharyngeal muscular dystrophy (OPMD) is an adult-onset
disease with worldwide distribution. It usually presents in the fifth or sixth decades with …

Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant disease that
presents in the fifth or sixth decade with dysphagia, ptosis and proximal limb weakness …

Abnormal trinucleotide repeat expansions alter protein conformation causing malfunction
and contribute to a significant number of incurable human diseases. Scarce structural …

Current theories on the origin of life reveal significant gaps in our understanding of the
mechanisms that allowed simple chemical precursors to coalesce into the complex polymers …

Ab initio quantum calculations are applied to both the parallel and the antiparallel
arrangements of the β-sheets of proteins. The energies of the NH⊙⊙⊙ O and CH⊙⊙⊙ O …

Short peptide sequences within the microtubule binding domain of the protein Tau are
proposed to be core nucleation sites for formation of amyloid fibrils displaying the paired …

Spiders that spin orb webs secrete seven types of silk. Although the spinning process of the
dragline thread is beginning to be understood, the molecular events that occur in spiders' …

Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disorder characterized by
progressive eyelid drooping, swallowing difficulties and proximal limb weakness. OPMD is …

In polyalanine (PA) diseases, the disease-causing transcription factors contain an
expansion of alanine repeats. While aggregated proteins that are responsible for the …