Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system,
emerging evidence points to CB2 playing a key role in regulating neuronal function in the …

Cumulative evidence has pointed out cannabinoid CB2 receptors (CB2r) as a potential
therapeutic key target for treating alcohol use disorder (AUD). This review provides the most …

It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on
central nervous system (CNS) function. In the 40 years since cannabinoids were found to …

Recent research indicates that brain cannabinoid CB2 receptors are involved in drug reward
and addiction. However, it is unclear whether β-caryophyllene (BCP), a natural product with …

Although the 3D structures of active and inactive cannabinoid receptors type 2 (CB2) are
available, neither the X-ray crystal nor the cryo-EM structure of CB2-orthosteric ligand …

Abstract Cannabinoid CB1 receptors (CB1Rs) have been major targets in medication
development for the treatment of substance use disorders. However, clinical trials with …

A growing body of research indicates that β-caryophyllene (BCP), a constituent present in a
large number of plants, possesses significant therapeutic properties against CNS disorders …

Addiction to psychostimulant drugs, such as cocaine, D-amphetamine, and
methamphetamine, is a public health issue that substantially contributes to the global …

Brain-stimulation reward, also known as intracranial self-stimulation (ICSS), is a commonly
used procedure for studying brain reward function and drug reward. In electrical ICSS …

Selective ligands of the CB2 receptor are receiving considerable attention due to their
potential as therapeutic agents for a variety of diseases. Recently, 7-hydroxy-5-oxopyrazolo …