Alkoxy radicals see the light: new paradigms of photochemical synthesis
Alkoxy radicals are highly reactive species that have long been recognized as versatile
intermediates in organic synthesis. However, their development has long been impeded due …
intermediates in organic synthesis. However, their development has long been impeded due …
Carbon–Carbon Bond Cleavage for Late-Stage Functionalization
YF Liang, M Bilal, LY Tang, TZ Wang, YQ Guan… - Chemical …, 2023 - ACS Publications
Late-stage functionalization (LSF) introduces functional group or structural modification at
the final stage of the synthesis of natural products, drugs, and complex compounds. It is …
the final stage of the synthesis of natural products, drugs, and complex compounds. It is …
Late-stage diversification of indole skeletons through nitrogen atom insertion
Compared with peripheral late-stage transformations mainly focusing on carbon–hydrogen
functionalizations, reliable strategies to directly edit the core skeleton of pharmaceutical lead …
functionalizations, reliable strategies to directly edit the core skeleton of pharmaceutical lead …
Skeletal editing through direct nitrogen deletion of secondary amines
SH Kennedy, BD Dherange, KJ Berger, MD Levin - Nature, 2021 - nature.com
Synthetic chemistry aims to build up molecular complexity from simple feedstocks. However,
the ability to exert precise changes that manipulate the connectivity of the molecular …
the ability to exert precise changes that manipulate the connectivity of the molecular …
[HTML][HTML] Zn-Nx sites on N-doped carbon for aerobic oxidative cleavage and esterification of C(CO)-C bonds
C Xie, L Lin, L Huang, Z Wang, Z Jiang, Z Zhang… - Nature …, 2021 - nature.com
Selective cleavage of CC bonds is very important in organic chemistry, but remains
challenging because of their inert chemical nature. Herein, we report that Zn/NC-X catalysts …
challenging because of their inert chemical nature. Herein, we report that Zn/NC-X catalysts …
Temporary or removable directing groups enable activation of unstrained C–C bonds
Y Xia, G Dong - Nature Reviews Chemistry, 2020 - nature.com
Abstract Carbon–carbon (C–C) bonds make up the skeletons of most organic molecules.
The selective manipulation of C–C bonds offers a direct approach to editing molecular …
The selective manipulation of C–C bonds offers a direct approach to editing molecular …
Direct deaminative functionalization
Selective functional group interconversions in complex molecular settings underpin many of
the challenges facing modern organic synthesis. Currently, a privileged subset of functional …
the challenges facing modern organic synthesis. Currently, a privileged subset of functional …
Photocatalytic dehydroxymethylative arylation by synergistic cerium and nickel catalysis
Y Chen, X Wang, X He, Q An, Z Zuo - Journal of the American …, 2021 - ACS Publications
Under mild reaction conditions with inexpensive cerium and nickel catalysts, easily
accessible free alcohols can now be utilized as operationally simple and robust carbon …
accessible free alcohols can now be utilized as operationally simple and robust carbon …
Copper‐Catalyzed C(sp3)‐Amination of Ketone‐Derived Dihydroquinazolinones by Aromatization‐Driven C−C Bond Scission
Herein, we describe the development of a copper‐catalyzed C (sp3)‐amination of
proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the …
proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the …
Site-specific and degree-controlled alkyl deuteration via Cu-catalyzed redox-neutral deacylation
Deuterated organic compounds have become increasingly important in many areas;
however, it remains challenging to install deuterium site-selectively to unactivated aliphatic …
however, it remains challenging to install deuterium site-selectively to unactivated aliphatic …