Alkoxy radicals are highly reactive species that have long been recognized as versatile
intermediates in organic synthesis. However, their development has long been impeded due …

Late-stage functionalization (LSF) introduces functional group or structural modification at
the final stage of the synthesis of natural products, drugs, and complex compounds. It is …

Compared with peripheral late-stage transformations mainly focusing on carbon–hydrogen
functionalizations, reliable strategies to directly edit the core skeleton of pharmaceutical lead …

Synthetic chemistry aims to build up molecular complexity from simple feedstocks. However,
the ability to exert precise changes that manipulate the connectivity of the molecular …

Selective cleavage of CC bonds is very important in organic chemistry, but remains
challenging because of their inert chemical nature. Herein, we report that Zn/NC-X catalysts …

Abstract Carbon–carbon (C–C) bonds make up the skeletons of most organic molecules.
The selective manipulation of C–C bonds offers a direct approach to editing molecular …

Selective functional group interconversions in complex molecular settings underpin many of
the challenges facing modern organic synthesis. Currently, a privileged subset of functional …

Under mild reaction conditions with inexpensive cerium and nickel catalysts, easily
accessible free alcohols can now be utilized as operationally simple and robust carbon …

Herein, we describe the development of a copper‐catalyzed C (sp3)‐amination of
proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the …

Deuterated organic compounds have become increasingly important in many areas;
however, it remains challenging to install deuterium site-selectively to unactivated aliphatic …