Prostate cancer is a hormone-dependent malignancy, whose onset and progression are
closely related to the activity of the androgen receptor (AR) signaling pathway. Due to this …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Sex bias exists in the development and progression of nonreproductive organ cancers, but
the underlying mechanisms are enigmatic. Studies so far have focused largely on sexual …

Tumor suppressors are mostly defined by inactivating mutations in tumors, yet little is known
about their epigenetic features in normal cells. Through integrative analysis of 1,134 …

While the antiandrogen enzalutamide (Enz) extends the castration resistant prostate cancer
(CRPC) patients' survival an extra 4.8 months, it might also result in some adverse effects via …

Androgen insensitivity syndrome (AIS) results from androgen receptor dysfunction and is a
common cause of disorder of sex development. The AIS phenotype largely depends on the …

Human nuclear receptors (NRs) are a superfamily of ligand-responsive transcription factors
that have central roles in cellular function. Their malfunction is linked to numerous diseases …

The constitutively active androgen receptor (AR) splice variant 7 (AR-V7) plays an important
role in the progression of castration-resistant prostate cancer (CRPC). Although biomarker …

Hepatocellular carcinoma (HCC) is a heterogeneous malignancy as a result of complex
genetic and epigenetic alterations. HCC is characterized by a clear gender disparity for …

Abstract The Androgen Receptor (AR) is the key-driving transcription factor in prostate
cancer, tightly controlled by epigenetic regulation. To date, most epigenetic profiling has …