When blood vessels are cut, the forces in the bloodstream increase and change character.
The dark side of these forces causes hemorrhage and death. However, von Willebrand …

Von Willebrand factor (VWF) is a blood glycoprotein that is required for normal hemostasis,
and deficiency of VWF, or von Willebrand disease (VWD), is the most common inherited …

The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in
extracellular matrix proteins, and in integrin receptors. A number of human diseases arise …

The adhesive protein von Willebrand factor (VWF) contributes to platelet function by
mediating the initiation and progression of thrombus formation at sites of vascular injury. In …

Von Willebrand disease (VWD) is one of the most common inherited bleeding diseases.
Based on a conservative estimate of prevalence (at least 100 per million persons)(1-7) and …

The cell wall envelope of Gram-positive bacteria can be thought of as a surface organelle for
the assembly of macromolecular structures that enable the unique lifestyle of each …

Here we describe a novel collagen belonging to the class of von Willebrand factor A (VWA)
domain-containing proteins. This novel protein was identified by screening the EST data …

The physiological protection against bleeding is secured by platelet adhesion to the site of
injury and sealing of the defect. The first step involves the arrest of platelets that have …

von Willebrand Factor (vWF) is a multimeric protein that mediates platelet adhesion to
exposed subendothelium at sites of vascular injury under conditions of high flow/shear. The …

We have determined the high resolution crystal structure of the I domain from the α-subunit
of the integrin α2β1, a cell surface adhesion receptor for collagen and the human pathogen …