Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials
S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
Artificial intelligence for natural product drug discovery
Developments in computational omics technologies have provided new means to access
the hidden diversity of natural products, unearthing new potential for drug discovery. In …
the hidden diversity of natural products, unearthing new potential for drug discovery. In …
MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters
With an ever-increasing amount of (meta) genomic data being deposited in sequence
databases,(meta) genome mining for natural product biosynthetic pathways occupies a …
databases,(meta) genome mining for natural product biosynthetic pathways occupies a …
microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data
Abstract microbeMASST, a taxonomically informed mass spectrometry (MS) search tool,
tackles limited microbial metabolite annotation in untargeted metabolomics experiments …
tackles limited microbial metabolite annotation in untargeted metabolomics experiments …
IMPPAT 2.0: An enhanced and expanded phytochemical atlas of Indian medicinal plants
Compilation, curation, digitization, and exploration of the phytochemical space of Indian
medicinal plants can expedite ongoing efforts toward natural product and traditional …
medicinal plants can expedite ongoing efforts toward natural product and traditional …
Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …
numerous biotechnological applications. The NP discovery process is expensive and time …
As we drink and breathe: Adverse health effects of microcystins and other harmful algal bloom toxins in the liver, gut, lungs and beyond
Freshwater harmful algal blooms (HABs) are increasing in number and severity worldwide.
These HABs are chiefly composed of one or more species of cyanobacteria, also known as …
These HABs are chiefly composed of one or more species of cyanobacteria, also known as …
Machine learning-enabled genome mining and bioactivity prediction of natural products
Natural products (NPs) produced by microorganisms and plants are a major source of drugs,
herbicides, and fungicides. Thanks to recent advances in DNA sequencing, bioinformatics …
herbicides, and fungicides. Thanks to recent advances in DNA sequencing, bioinformatics …
[HTML][HTML] Antibiotics from rare actinomycetes, beyond the genus Streptomyces
Throughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for
their ability to produce bioactive metabolites. Yet, this success has been hampered by …
their ability to produce bioactive metabolites. Yet, this success has been hampered by …
Recent advances in mass spectrometry-based computational metabolomics
The computational metabolomics field brings together computer scientists, bioinformaticians,
chemists, clinicians, and biologists to maximize the impact of metabolomics across a wide …
chemists, clinicians, and biologists to maximize the impact of metabolomics across a wide …