Organ transplantation is the most effective therapy for patients with end-stage disease.
Preservation solutions and techniques are crucial for donor organ quality, which is directly …

Extracorporeal circulation (ECC) systems, including cardiopulmonary bypass, and
extracorporeal membrane oxygenation have been an irreplaceable part of the …

Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the
use of most donor lungs. Although ex vivo lung perfusion (EVLP) is able to recover marginal …

Improved approaches to expanding the pool of donor lungs suitable for transplantation are
critically needed for the growing population with end-stage lung disease. Cross-circulation …

Normothermic machine perfusion (NMP) aims to preserve organs ex vivo by simulating
physiological conditions such as body temperature. Recent advancements in NMP system …

Disparities at the major histocompatibility complex (MHC) antigens and associated minor
antigens trigger harmful immune responses, leading to graft rejection after transplantation …

Ex vivo lung perfusion implies perfusion and ventilation of a donor lung outside of the
human body. The 2 most clinically relevant and commercially available devices currently in …

Background Ex vivo lung perfusion (EVLP) is used by an increasing number of transplant
centres. It is still controversial whether an acellular or cellular (erythrocyte enriched) …

Portable normothermic EVLP has been evaluated in clinical trials using standard and
extended‐criteria donor lungs. We describe a swine model of lung transplant following …

The availability of thoracic organ transplantation as the treatment of choice for end-stage
cardiac or pulmonary diseases is limited by the insufficient number of donor organs from …