Bone marrow mesenchymal stem cells (BMSCs) are multi-potent cell populations and are
capable of maintaining bone and body homeostasis. The stemness and potential …

Some of the earliest success in de novo tissue generation was in bone tissue, and
advances, facilitated by the use of endogenous and exogenous progenitor cells, continue …

Skeletal disorders are commonly diagnosed by X-ray imaging, but the radiation limits its use.
Optical imaging through the near-infrared-II window (NIR-II, 1000–1700 nm) can penetrate …

Background: Mechanical loading and alendronate (ALN) can be used as noninvasive
physical therapy methods for osteoarthritis (OA). However, the timing and efficacy for …

The lack of a functional vascular supply has been identified as a major challenge limiting the
clinical introduction of stem cell-based bone tissue engineering (BTE) for the repair of large …

Insufficient bone fracture repair represents a major clinical and societal burden and novel
strategies are needed to address it. Our data reveal that the transforming growth factor-β …

The healing capacity of bones after fracture implies the existence of adult regenerative cells.
However, information on identification and functional role of fracture-induced progenitors is …

Fracture healing is a complex, multistep process that is highly sensitive to mechanical
signaling. To optimize repair, surgeons prescribe immediate weight-bearing as-tolerated …

Mesenchymal stromal cells (MSCs) transplantation could enhance bone repair. However,
the cell fate of transplanted MSCs, in terms of their local distribution and spatial associations …

Background Skeletal unloading can induce severe disuse osteopenia that often occurs in
spaceflight astronauts or in patients subjected to prolonged bed-rest or immobility …