Huntington's disease: mechanisms of pathogenesis and therapeutic strategies
M Jimenez-Sanchez, F Licitra… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Huntington's disease is a late-onset neurodegenerative disease caused by a CAG
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …
Huntington disease: natural history, biomarkers and prospects for therapeutics
CA Ross, EH Aylward, EJ Wild, DR Langbehn… - Nature Reviews …, 2014 - nature.com
Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …
caused by a single genetic mutation and is amenable to predictive genetic testing, with …
Mitochondria and neuroplasticity
A Cheng, Y Hou, MP Mattson - ASN neuro, 2010 - journals.sagepub.com
The production of neurons from neural progenitor cells, the growth of axons and dendrites
and the formation and reorganization of synapses are examples of neuroplasticity. These …
and the formation and reorganization of synapses are examples of neuroplasticity. These …
Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function
LA Raymond, VM André, C Cepeda, CM Gladding… - Neuroscience, 2011 - Elsevier
Huntington's disease (HD) is a progressive, fatal neurological condition caused by an
expansion of CAG (glutamine) repeats in the coding region of the Huntington gene. To date …
expansion of CAG (glutamine) repeats in the coding region of the Huntington gene. To date …
[HTML][HTML] Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease
AJ Milnerwood, LA Raymond - Trends in neurosciences, 2010 - cell.com
Investigations of synaptic transmission and plasticity in mouse models of Huntington's
disease (HD) demonstrate neuronal dysfunction long before the onset of classical disease …
disease (HD) demonstrate neuronal dysfunction long before the onset of classical disease …
[HTML][HTML] Cortical and striatal circuits in Huntington's disease
S Blumenstock, I Dudanova - Frontiers in neuroscience, 2020 - frontiersin.org
Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically
manifests in midlife with motor, cognitive, and/or psychiatric symptoms. The disease is …
manifests in midlife with motor, cognitive, and/or psychiatric symptoms. The disease is …
The corticostriatal pathway in Huntington's disease
C Cepeda, N Wu, VM André, DM Cummings… - Progress in …, 2007 - Elsevier
The corticostriatal pathway provides most of the excitatory glutamatergic input into the
striatum and it plays an important role in the development of the phenotype of Huntington's …
striatum and it plays an important role in the development of the phenotype of Huntington's …
Alterations in synaptic function and plasticity in Huntington disease
AI Smith‐Dijak, MD Sepers… - Journal of …, 2019 - Wiley Online Library
Huntington disease (HD) is an inherited neurodegenerative disorder caused by an
expansion of the CAG repeat region in the first exon of the huntingtin gene …
expansion of the CAG repeat region in the first exon of the huntingtin gene …
[HTML][HTML] Huntington's disease: can mice lead the way to treatment?
ZR Crook, D Housman - Neuron, 2011 - cell.com
Mouse models for Huntington's Disease (HD) and HD patients demonstrate motor and
behavioral dysfunctions, such as progressive loss of coordination and memory, and share …
behavioral dysfunctions, such as progressive loss of coordination and memory, and share …
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway
involved during embryonic development and later life stages. Further, it regulates cell …
involved during embryonic development and later life stages. Further, it regulates cell …