Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved
in the regulation of fundamental cellular processes, including transcription, RNA processing …

Covalent modification of proteins with ubiquitin is essential for the majority of biological
processes in mammalian cells. Numerous proteins are conjugated with single or multiple …

The mammalian target of rapamycin complex1 (mTORC1) is a central regulator of
metabolism and cell growth by sensing diverse environmental signals, including amino …

PRMT1, the major protein arginine methyltransferase in mammals, catalyzes
monomethylation and asymmetric dimethylation of arginine side chains in proteins. Initially …

Ubiquitin (UB) transfer cascades consisting of E1, E2, and E3 enzymes constitute a complex
network that regulates a myriad of biologic processes by modifying protein substrates …

Protein arginine methyltransferase (PRMT)-mediated arginine methylation is an important
post-transcriptional modification that regulates various cellular processes including …

CBX3, also known as HP1γ, is a major isoform of heterochromatin protein 1, whose
deregulation has been reported to promote the development of human cancers. However …

Highlights•Targeted-protein degradation supports fundamental discovery and drug
development.•Biologics-based degraders target intracellular, extracellular, and membrane …

The ubiquitin-proteasome system (UPS) modulates carcinogenesis through ubiquitination of
cancer-related target proteins, leading to their degradation in the proteasome. This may …

The Ubiquitin Proteasome System (UPS) is responsible for the degradation of misfolded or
aggregated proteins via a multistep ATP-dependent proteolytic mechanism. This process …