Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …

Prostate cancer is the second most common malignancy in men and androgen deprivation
therapy is the first‐line therapy. However, most cases will eventually develop castration …

Ferroptosis is a type of programmed cell death induced by the accumulation of lipid
peroxidation and lipid reactive oxygen species in cells. It has been recently demonstrated …

Abstract c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression.
Although MYC is overexpressed in both early and metastatic disease and associated with …

Androgen receptor (AR) in prostate cancer (PCa) can drive transcriptional repression of
multiple genes including MYC, and supraphysiological androgen is effective in some …

Mechanisms regulating DNA repair processes remain incompletely defined. Here, the
circadian factor CRY1, an evolutionally conserved transcriptional coregulator, is identified as …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

MYC regulates multiple gene programs, raising questions about the potential selectivity and
downstream transcriptional consequences of MYC inhibitors as cancer therapeutics. Here …

Aberrant hyperactivation of cyclins results in carcinogenesis and therapy resistance in
cancers. Direct degradation of the specific cyclin or cyclin-dependent kinase (CDK)-cyclin …

Background Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C
have been detected by whole exome sequencing studies in various cancers, including …