Background In the 5 years that have passed since the publication of the 2018 International
Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis …

Allergic rhinitis is a symptomatic disorder of the nose induced after allergen exposure by an
immunoglobulin E (IgE)-mediated inflammation of the membranes lining the nose (1). It was …

BACKGROUND: Otitis media with effusion (OME) is a chronic inflammatory disease of the
middle ear space characterized by the accumulation of fluid. Previous investigations have …

Allergic rhinitis (AR) is a disease with growing impact on everyday medical practice, as its
prevalence has steadily increased during the last decades. Immunoglobulin‐E (IgE) …

The significant incidence of atopy associated with otitis media with effusion (OME) has
suggested a role of allergy in the pathogenesis of OME. Analysis of inflammatory mediators …

Otitis media with effusion (OME) is the major form of chronic relapsing inflammatory disease
of the middle ear. It is a clinical disease defined as the presence of fluid in the middle ear …

Objectives Otitis media with effusion (OME) may be caused by various factors including
Eustachian tube dysfunction, inflammatory response as well as atopy. Allergic rhinitis (AR), a …

Background Chronic rhinosinusitis (CRS) and asthma frequently coexist in children and
adults. However, the precise pathophysiologic mechanism of this interaction is still poorly …

Background Patients with intractable otitis media associated with bronchial asthma have an
extensive accumulation of eosinophils in the effusion and mucosa of the middle ear; this …

OBJECTIVE: Controversy persists over the significance of allergy as it might relate to chronic
middle-ear disease as no controlled study of the efficacy of allergy immunotherapy has been …