Molecular and cellular understanding of psoriasis pathogenesis has evolved considerably
over the last 30 years beginning in the early 1980s when psoriasis was thought to be a skin …

The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

Interleukin-17A (IL-17A) is elaborated by the T helper 17 (TH17) subset of TH cells and
exhibits potent proinflammatory properties in animal models of autoimmunity, including …

GAO, Jintao et al. Daphnetin inhibits proliferation and inflammatory response in human
HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice …

Psoriasis pathogenesis is closely associated with disease‐inducing Th1 and Th17 cells. Yet,
several studies suggest that aberrant keratinocyte or endothelial cell signalling significantly …

Background Th17 cells are a lineage of proinflammatory T helper cells producing interleukin
(IL)‐17. The importance of Th17 cells in inflammation and autoimmunity has now been …

Keratinocytes play a crucial role in the regulation of skin inflammation, responding to
environmental and immune cells stimuli. They produce soluble factors that can act in an …

The cytokine-encoding messenger RNA (mRNA) molecules transcribed in the nucleus
acquire a protein coat that facilitates nuclear export, influences cytoplasmic localization, and …

TNF-α induces some proinflammatory cytokines including IL-1β, IL-6, IL-8, and itself by
activation of NF-κB or MAPKs (p38, JNK, ERK). These cytokines play important roles in …

Mitogen-activated protein kinase (MAPK) pathways are implicated in several cellular
processes including proliferation, differentiation, apoptosis, cell survival, cell motility …