Despite improvements in interventional and pharmacological therapy for atherosclerotic
disease, it is still the leading cause of death in the developed world. Hence, there is a need …

Tissue factor (TF), formerly known as thromboplastin, is the key initiator of the coagulation
cascade; it binds factor VIIa resulting in activation of factor IX and factor X, ultimately leading …

Atherosclerosis is a chronic inflammatory disease that is characterized by the formation of
lipid rich plaques in the wall of medium to large sized arteries. Atherothrombosis represents …

Simple Summary Tissue factor is a protein that is important for the regulation of blood
coagulation. New research has highlighted the important roles of tissue factor in cancer. This …

How does tissue factor (TF), whose principle role is to support clotting factor VIIa (FVIIa) in
triggering the coagulation cascade, affect various pathophysiological processes? One of the …

Objective: Inflammation plays a pivotal role in atherothrombosis. In addition to being a
prognostic marker for major cardiovascular events, recent data indicate that C-reactive …

For many years, the attention on tissue factor (TF) in human pathophysiology has been
limited to its role as initiator of extrinsic coagulation pathway. Moreover, it was described as …

Objective: Atherosclerosis is a chronic inflammatory process, in which vascular endothelial
cells (ECs) become dysfunctional owing to the effects of chemical substances, such as …

Rationale: Activation of the coagulation cascade has been demonstrated in pulmonary
fibrosis. In addition to its procoagulant function, various coagulation proteases exhibit …

Receptors for extracellular nucleotides are the focus of increasing attention for their ability to
cause release of plasma membrane vesicles (micropar‐ticles, MPs). Here, we show that …