▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the developing nervous system …

Direct-current (DC) electric fields are present in all developing and regenerating animal
tissues, yet their existence and potential impact on tissue repair and development are …

The four mammalian neurotrophins—NGF, BDNF, NT-3 and NT-4—each bind and activate
one or more of the Trk family of receptor tyrosine kinases. Through these receptors …

Netrins are secreted proteins that were first identified as guidance cues, directing cell and
axon migration during neural development. Subsequent findings have demonstrated that …

Motile growth cones lead growing axons through developing tissues to synaptic targets.
These behaviors depend on the organization and dynamics of actin filaments that fill the …

Growth cones contain mRNAs, translation machinery, and, as we report here, protein
degradation machinery. We show that isolated retinal growth cones immediately lose their …

Over a half a century of research has confirmed that neurotrophic factors promote the
survival and process outgrowth of isolated neurons in vitro. The mechanisms by which …

▪ Abstract The guidance of axons during the establishment of the nervous system is
mediated by a variety of extracellular cues that govern cytoskeletal dynamics in axonal …