The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Mitochondrial dysfunction has been implicated in the pathogenesis of almost all
neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in …

Cannabis has a long history of anecdotal medicinal use and limited licensed medicinal use.
Until recently, alleged clinical effects from anecdotal reports and the use of licensed …

Proper function of the endoplasmic reticulum (ER) and mitochondria is crucial for cellular
homeostasis, and dysfunction at either site has been linked to pathophysiological states …

Abstract Calcium (Ca 2+) is an universal second messenger that regulates the most
important activities of all eukaryotic cells. It is of critical importance to neurons as it …

Cockayne syndrome (CS) is a disorder characterized by a variety of clinical features
including cachectic dwarfism, severe neurological manifestations including microcephaly …

Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …

Calcium ions are highly versatile intracellular signals that regulate many cellular processes.
The key to achieving this pleiotropic role is the spatiotemporal control of calcium …

The ketogenic diet (KD) is a broad-spectrum therapy for medically intractable epilepsy and is
receiving growing attention as a potential treatment for neurological disorders arising in part …

Background Recent clinical and experimental studies have highlighted the involvement of
Ventral Tegmental Area (VTA) dopamine (DA) neurons for the early pathogenesis of …