As the demand for metal resources increases and the quality and availability of rich ore
resources decline, the focus is shifting to low-cost, eco-friendly bioleaching technologies that …

The metal-resistant bacterium Cupriavidus metallidurans uses its copper resistance
components to survive the synergistic toxicity of copper ions and gold complexes in …

Toxic metals are known to inhibit DNA repair but the underlying mechanisms of inhibition
are still not fully understood. DNA repair enzymes such as human uracil-DNA glycosylase …

Escherichia coli CusCBAF represents an important class of bacterial efflux pump exhibiting
selectivity towards Cu (I) and Ag (I). The complex is comprised of three proteins: the CusA …

Obtaining a detailed description of how active site flap motion affects substrate or ligand
binding will advance structure-based drug design (SBDD) efforts on systems including the …

Remains of a medieval foundry were excavated by archaeologists in 2013 in Verdun
(France). Ancient workshops specialized in brass and copper alloys were found with an …

Mononuclear copper monooxygenases peptidylglycine monooxygenase (PHM) and
dopamine β-monooxygenase (DBM) catalyze the hydroxylation of high energy C–H bonds …

Bacteria maintain copper balance by various copper response mechanisms. A plasmid gene
encoding a methionine rich protein targeted to periplasm is adjacent to the sil operon that …

A theoretical study was performed to evaluate the defersirox potency to chelate aluminum
(Al) and gallium (Ga) as the toxic metals in biological systems. Deferasirox as an important …

Metal ions play fundamental roles in geochemistry, biochemistry and materials science. With
the tremendous increasing power of the computational resources and largely inventions of …