Design, Synthesis, Molecular Docking, Molecular Dynamics and In Vivo Antimalarial Activity of New Dipeptide‐Sulfonamides

JA Ezugwu, UC Okoro, MA Ezeokonkwo… - …, 2022 - Wiley Online Library
A new series of novel dipeptide sulfonamide analogues were designed, synthesized, and
screened for their in silico studies and in vivo antimalarial activities. The synthesized …

Design, Synthesis, Molecular Docking, Drug-Likeness/ADMET and Molecular Dynamics Studies of Thiazolyl Benzenesulfonamide Carboxylates as Antimalarial …

JA Ezugwu, UC Okoro, MA Ezeokonkwo… - Chemistry Africa, 2024 - Springer
In this work, nine novel thiazole derivatives of substituted benzenesulfonamide carboxylate
were designed, synthesized and characterized (1H NMR, 13C NMR and Mass Spectra) for …

Synthesis, in silico studies and investigations on antimicrobial, antimalarial activities of p-toluenesulphonamoyl 'Leu-Gly'dipeptide carboxamide derivatives

EL Ayuk, UC Okoro, CU Ibeji, CM Nkambule - Journal of Molecular …, 2023 - Elsevier
Six novel leucine-glycine dipeptide sulphonamide deriavtives were synthesized and
characterized via 1 HNMR, 13 CNMR, FTIR and HRMS spectroscopic techniques. The in …

A novel bioinformatic method for the identification of antimicrobial peptides in metagenomes

J Megaw, T Skvortsov, G Gori, AI Dabai… - Journal of Applied …, 2024 - academic.oup.com
Aims This study aimed to develop a new bioinformatic approach for the identification of
novel antimicrobial peptides (AMPs), which did not depend on sequence similarity to known …

Effect of Leu/Val mutation on the energetics of antimicrobial peptide: micelle binding

S Ghosh, S Chatterjee, P Satpati - The Journal of Physical …, 2022 - ACS Publications
Recently, we had reported a synthetic positively charged leucine-rich 14-residue-long
antimicrobial peptide (AMP, LL-14: NH3+-LKWLKKLLKWLKKL-CONH2), which was highly …

New substituted benzenesulphonamoyl 'Cys-Gly'dipeptide carboxamide derivatives: Design, synthesis, characterization and pharmacological studies

TO Oni, EL Ayuk, UC Okoro - Bioorganic Chemistry, 2024 - Elsevier
Abstract Twelve new sulphonamide (Cys-Gly) dipeptide carboxamide derivatives 17a–17l
were designed, prepared and characterized through spectroscopic techniques and their …

Evaluation of glycyl-arginine and lysyl-aspartic acid dipeptides for their antimicrobial, antibiofilm, and anticancer potentials

H Sevim Akan, G Şahal, TD Karaca, ÖA Gürpınar… - Archives of …, 2023 - Springer
Antibacterial resistance and cancer are worldwide challenges and have been defined as
major threats by international health organizations. Peptides are produced naturally by all …

Synthesis and Biological Evaluation of Dipeptide-Based Stilbene Derivatives Bearing a Biheterocyclic Moiety as Potential Fungicides

Y Zhu, X Lin, L Wen, D He - Molecules, 2022 - mdpi.com
The escalating demand for crop production, environmental protection, and food safety
warrants the development of new fungicides with greater efficiency, environmental …

Antimicrobial, Antibiofilm and Anticancer Potentials of Glycine and Glycyl-Glycine; an in vitro study

G Sahal, HS Akan, TD Karaca - Hacettepe Journal of Biology and …, 2024 - dergipark.org.tr
Globally, there is a huge demand for novel agents capable of providing protection against
both pathogen microorganisms and tumor cells. In this study, the antimicrobial, biofilm …

[PDF][PDF] Antimicrobial, Antibiofilm and Anticancer Potentials of Glycine and Glycyl-Glycine; an in vitro study Glisin ve Glisil-Glisinin Antimikrobiyal, Antibiyofilm ve …

G Şahal, HS Akan, TD Karaca - hjbc.hacettepe.edu.tr
ÖZ Küresel anlamda, hem patojen mikroorganizmalara karşı koruma sağlayabilen hem de
tümör hücrelerine karşı etkili olabilen yeni ajanlara karşı büyük bir talep bulunmaktadır. Bu …