Rheumatoid Arthritis — Common Origins, Divergent Mechanisms | New England Journal of
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Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …

Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction. There is currently no cure for rheumatoid arthritis, and the effectiveness of …

The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis
(RA) remain poorly defined. Although increased levels of CD8+ T cells have been described …

Immune checkpoint receptors such as programmed cell death protein 1 (PD-1), cytotoxic T-
lymphocyte associated protein 4 (CTLA-4), lymphocyte-activation gene 3 (LAG-3), and T cell …

Aims Aging is a dominant driver of atherosclerosis and induces a series of immunological
alterations, called immunosenescence. Given the demographic shift towards elderly …

In autoimmune diseases such as rheumatoid arthritis, the immune system attacks the body's
own cells. Developing a precise understanding of the cell states where noncoding …

Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial
butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in …

Primary Sjögren's syndrome (pSS) is a systemic autoimmune inflammatory disease mainly
defined by T cell–dominated destruction of exocrine glands. Currently, CD8+ T cells are …

Abstract NK cells and CD8 T cells use cytotoxic molecules to kill virally infected and tumor
cell targets. While perforin and granzyme B (GzmB) are the most commonly studied lytic …