Rheumatoid arthritis—common origins, divergent mechanisms
EM Gravallese, GS Firestein - New England Journal of Medicine, 2023 - Mass Medical Soc
Rheumatoid Arthritis — Common Origins, Divergent Mechanisms | New England Journal of
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The pathogenesis of rheumatoid arthritis
S Alivernini, GS Firestein, IB McInnes - Immunity, 2022 - cell.com
Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …
[HTML][HTML] Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes
Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction. There is currently no cure for rheumatoid arthritis, and the effectiveness of …
and destruction. There is currently no cure for rheumatoid arthritis, and the effectiveness of …
Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis
The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis
(RA) remain poorly defined. Although increased levels of CD8+ T cells have been described …
(RA) remain poorly defined. Although increased levels of CD8+ T cells have been described …
Immune checkpoint receptors in autoimmunity
KP Burke, DG Patterson, D Liang, AH Sharpe - Current opinion in …, 2023 - Elsevier
Immune checkpoint receptors such as programmed cell death protein 1 (PD-1), cytotoxic T-
lymphocyte associated protein 4 (CTLA-4), lymphocyte-activation gene 3 (LAG-3), and T cell …
lymphocyte associated protein 4 (CTLA-4), lymphocyte-activation gene 3 (LAG-3), and T cell …
Single-cell profiling reveals age-associated immunity in atherosclerosis
V Smit, J de Mol, FH Schaftenaar… - Cardiovascular …, 2023 - academic.oup.com
Aims Aging is a dominant driver of atherosclerosis and induces a series of immunological
alterations, called immunosenescence. Given the demographic shift towards elderly …
alterations, called immunosenescence. Given the demographic shift towards elderly …
Dynamic regulatory elements in single-cell multimodal data implicate key immune cell states enriched for autoimmune disease heritability
In autoimmune diseases such as rheumatoid arthritis, the immune system attacks the body's
own cells. Developing a precise understanding of the cell states where noncoding …
own cells. Developing a precise understanding of the cell states where noncoding …
Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease
RJ Dart, I Zlatareva, P Vantourout, E Theodoridis… - Science, 2023 - science.org
Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial
butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in …
butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in …
[HTML][HTML] Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+ CD8+ T cells in primary Sjögren's syndrome
T Xu, HX Zhu, X You, JF Ma, X Li, PY Luo, Y Li… - JCI insight, 2023 - ncbi.nlm.nih.gov
Primary Sjögren's syndrome (pSS) is a systemic autoimmune inflammatory disease mainly
defined by T cell–dominated destruction of exocrine glands. Currently, CD8+ T cells are …
defined by T cell–dominated destruction of exocrine glands. Currently, CD8+ T cells are …
Human Granzyme K is a feature of innate T cells in blood, tissues, and tumors, responding to cytokines rather than TCR stimulation
D Duquette, C Harmon, A Zaborowski… - The Journal of …, 2023 - journals.aai.org
Abstract NK cells and CD8 T cells use cytotoxic molecules to kill virally infected and tumor
cell targets. While perforin and granzyme B (GzmB) are the most commonly studied lytic …
cell targets. While perforin and granzyme B (GzmB) are the most commonly studied lytic …