The ability of human pluripotent stem cells to form all cells of the body has provided many
opportunities to study disease and produce cells that can be used for therapy in …

Bone morphogenetic proteins (BMPs) are dimeric transforming growth factor ß (TGFß) family
cytokines that were first described in bone and cartilage formation but have since been …

Compact cardiomyocytes that make up the ventricular wall of the adult heart represent an
important therapeutic target population for modeling and treating cardiovascular diseases …

The heart, which is the first organ to develop, is highly dependent on its form to function,.
However, how diverse cardiac cell types spatially coordinate to create the complex …

In the history of biomedicine and biomedical devices, heart valve manufacturing techniques
have undergone a spectacular evolution. However, important limitations in the development …

The contribution of endocardial cells (EdCs) to the hematopoietic lineages has been
strongly debated. Here, we provide evidence that in zebrafish, the endocardium gives rise to …

Endothelial cells (ECs) sense and respond to fluid flow and regulate immune cell trafficking
in all organs. Despite sharing the same mesodermal origin, ECs exhibit heterogeneous …

The cardiac crescent is the first structure of the heart and contains progenitor cells of the first
heart field, which primarily differentiate into left ventricular cardiomyocytes. The interface …

Surgical replacement remains the primary option to treat the rapidly growing number of
patients with severe valvular heart disease. Although current valve replacements …

It has been nearly 15 years since the discovery of human-induced pluripotent stem cells
(iPSCs). During this time, differentiation methods to targeted cells have dramatically …