Porcine spinal cord injury model for translational research across multiple functional systems

RU Ahmed, CA Knibbe, F Wilkins, LC Sherwood… - Experimental …, 2023 - Elsevier
Animal models are necessary to identify pathological changes and help assess therapeutic
outcomes following spinal cord injury (SCI). Small animal models offer value in research in …

Effects of pituitary adenylate cyclase activating polypeptide in the urinary system, with special emphasis on its protective effects in the kidney

D Reglodi, P Kiss, G Horvath, A Lubics, E Laszlo… - Neuropeptides, 2012 - Elsevier
Pituitary adenylate cyclase activating polypeptide (PACAP) is a widespread neuropeptide
with diverse effects in the nervous system and peripheral organs. One of the most well …

Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neurons

LE Cornelison, JL Hawkins, PL Durham - Neuroscience, 2016 - Elsevier
Orofacial pain conditions including temporomandibular disorder (TMD) and migraine are
characterized by peripheral and central sensitization of trigeminal nociceptive neurons. The …

Early sacral neuromodulation ameliorates urinary bladder function and structure in complete spinal cord injury minipigs

EE Keller, I Patras, I Hutu, K Roider… - Neurourology and …, 2020 - Wiley Online Library
Aims To determine the effects of early sacral neuromodulation (SNM) and pudendal
neuromodulation (PNM) on lower urinary tract (LUT) function, minipigs with complete spinal …

Morphological and phenotypical characteristics of porcine satellite glial cells of the dorsal root ganglia

I Zdora, L Jubran, L Allnoch, F Hansmann… - Frontiers in …, 2022 - frontiersin.org
Satellite glial cells (SGCs) of the dorsal root ganglia (DRG) ensure homeostasis and
proportional excitability of sensory neurons and gained interest in the field of development …

Neurochemical features of boar lumbosacral dorsal root ganglion neurons and characterization of sensory neurons innervating the urinary bladder trigone

D Russo, P Clavenzani, C Sorteni… - Journal of …, 2013 - Wiley Online Library
Porcine lumbosacral dorsal root ganglion (DRG) neurons were neurochemically
characterized by using six neuronal markers: calcitonin gene‐related peptide (CGRP) …

[HTML][HTML] Structural changes of the urinary bladder after chronic complete spinal cord injury in minipigs

EE Foditsch, K Roider, I Patras, I Hutu… - International …, 2017 - ncbi.nlm.nih.gov
Purpose The aim of this study was to determine the structural changes of the urinary bladder
after chronic spinal cord injury (SCI) in minipigs with the primary focus on the analysis of …

Examination of PACAP-like immunoreactivity in urogenital tumor samples

A Tamas, A Javorhazy, D Reglodi, DP Sarlos… - Journal of Molecular …, 2016 - Springer
Numerous studies investigated the localization of pituitary adenylate cyclase-activating
polypeptide (PACAP) and its receptors in different tumors and described the effects of …

Botulinum toxin type A induces changes in the chemical coding of substance P-immunoreactive dorsal root ganglia sensory neurons supplying the porcine urinary …

A Bossowska, E Lepiarczyk, U Mazur, P Janikiewicz… - Toxins, 2015 - mdpi.com
Botulinum toxin (BTX) is a potent neurotoxin which blocks acetylcholine release from nerve
terminals, and therefore leads to cessation of somatic motor and/or parasympathetic …

Pharmacogenetic inhibition of lumbosacral sensory neurons alleviates visceral hypersensitivity in a mouse model of chronic pelvic pain

AX Xie, N Iguchi, TC Clarkson, AP Malykhina - Plos one, 2022 - journals.plos.org
The study investigated the cellular and molecular mechanisms in the peripheral nervous
system (PNS) underlying the symptoms of urologic chronic pelvic pain syndrome (UCPPS) …