Mechanisms in endocrinology: the crosstalk between thyroid gland and adipose tissue: signal integration in health and disease

F Santini, P Marzullo, M Rotondi… - European journal of …, 2014 - academic.oup.com
Obesity and thyroid diseases are common disorders in the general population and they
frequently occur in single individuals. Alongside a chance association, a direct relationship …

Ghrelin as a promising therapeutic option for cancer cachexia

MN Khatib, A Gaidhane, S Gaidhane… - Cellular Physiology and …, 2018 - karger.com
Cachexia is a devastating complication of cancer and an important cause of morbidity and
mortality and can have a great effect on quality of life, and sense of self-esteem …

The impact of ghrelin in metabolic diseases: an immune perspective

JAS Pereira, FC Silva… - Journal of diabetes …, 2017 - Wiley Online Library
Obesity and insulin resistance have reached epidemic proportions. Obesogenic conditions
are associated with increased risk for the development of other comorbidities and obesity …

[HTML][HTML] Ghrelin and cancer progression

TC Lin, M Hsiao - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2017 - Elsevier
Ghrelin is a small peptide with 28 amino acids, and has been characterized as the ligand of
the growth hormone secretagogue receptor (GHSR). In addition to its original function in …

Cancer as a proinflammatory environment: metastasis and cachexia

N Inácio Pinto, J Carnier, LM Oyama… - Mediators of …, 2015 - Wiley Online Library
The development of the syndrome of cancer cachexia and that of metastasis are related with
a poor prognostic for cancer patients. They are considered multifactorial processes …

In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features

A Ibánez-Costa, MD Gahete, E Rivero-Cortés… - Scientific reports, 2015 - nature.com
Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious
comorbidities, which would benefit from identification of novel, common molecular/cellular …

Attribution of ghrelin to cancer; attempts to unravel an apparent controversy

S Soleyman-Jahi, F Sadeghi… - Frontiers in …, 2019 - frontiersin.org
Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been
known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate …

The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness

D Hormaechea-Agulla, MD Gahete… - Molecular cancer, 2017 - Springer
Abstract Background The Ghrelin-system is a complex, pleiotropic family composed of
several peptides, including native-ghrelin and its In1-ghrelin splicing variant, and receptors …

Role of the ghrelin system in colorectal cancer

A Kasprzak - International Journal of Molecular Sciences, 2022 - mdpi.com
The ghrelin system contains several components (eg, ghrelin with growing number of
alternative peptides, growth hormone secretagogue receptors (GHS-Rs), and ghrelin-O-acyl …

Is there an effect of ghrelin/ghrelin analogs on cancer? A systematic review

S Sever, DL White, JM Garcia - Endocrine-related cancer, 2016 - erc.bioscientifica.com
Ghrelin is a hormone with multiple physiologic functions, including promotion of growth
hormone release, stimulation of appetite and regulation of energy homeostasis. Treatment …